Sabotaging a host immune response

Question 1

what are the 4 mechanisms pathogens use to subvert or sabotage a host immune response

Answer 1

inhibit humoral immunity, inhibit inflammatory responses, block Ag processing, immunosuppression

Question 2

staphylococcus aureus secretes ____ that bind to the Fc of IgA and prevents phagocytosis & complement. this is an example of inhibiting humoral immunity

Answer 2

SSLPs: staphylococcal superantigen-like proteins

Question 3

3 mechanisms within inhibition of humoral immunity

Answer 3

virally encoded Fc receptor, virally encoded complement receptor, virally encoded complement protein

Question 4

4 mechanisms within inhibition of inflammatory response

Answer 4

chemokine, cytokine, adhesion, TLR/NFKB

Question 5

2 mechanisms within blocking of antigen processing

Answer 5

block IFN gamma signaling, inhibition of peptide transport by TAP

Question 6

what does inhibiting MHC Class I upregulation by IFN gamma signaling do

Answer 6

impairs recognition of Ag presenting cells by CD4 T cells

Question 7

what does inhibiting TAP do

Answer 7

blocks peptide association with MHC I

Question 8

what is the mechanism for immunosuppression

Answer 8

viruses encode for IL-10 homologs that lead to immunosuppression