S3_L3: Lower Motor Neuron Flashcards
This is also known as Gehrig’s Disease
Amyotrophic Lateral Sclerosis
Enumerate the hierarchy of initial symptoms of ALS patients.
- Leg weakness
- Arm weakness
- Bulbar Involvement
- Generalized weakness
Phenomenon characterized by weight loss due to muscle atrophy and reduced caloric intake.
Cachexia
Gold standard used to Dx UMN pathology
Presence of Pathologic Reflexes
Determine if the following is an UMN or LMN sx.
- Fasciculations
- Hyperreflexia
- Spasticity
- (+) Corneomandibular reflex
- Cramps
A. LMN
B. UMN
- A
- B
- B
- B
- A
Determine if the following is an UMN or LMN sx.
- Flaccid Dysarthria
- Muscle Atrophy
- Cramps
- (+) Hoffman’s Sign
- (+) Jaw jerk
A. LMN
B. UMN
- A
- A
- A
- B
- B
Most common adult motor neuron disease
Amyotrophic Lateral Sclerosis
UMN syndrome caused by motor neuron loss in the corticobulbar tracts
Pseudobulbar Affect
This UMN condition involves the corticospinal tract and DCML.
Hereditary Spastic Paraplegia
Hereditary d/o causing degeneration of motor neurons and leading to weakness and atrophy of skeletal muscles.
Spinal Muscular Atrophy
This is also known as Acute Ascending Symmetrical Polyneuropathy
Guillain Barre Syndrome
This condition has a triad of Ataxia, Areflexia, and Ophthalmoplegia.
Miller-Fisher Syndrome (MFS)
Determine which condition is being described through the following s/sx or details.
- 2nd Wind Phenomenon
- Initially with strength, then decreases
- Decreased ACH receptors
- Pre-synaptic
- M > F
A. Myasthenia Gravis
B. Lambert-Eaton
- B
- A
- A
- B
- B
Determine which condition is being described.
- Associated with thymoma
- Associated with bronchogenic carcinoma
- Ptosis and diplopia – initial manifestations
- Sexual dysfunction
- Post-synaptic
A. Myasthenia Gravis
B. Lambert-Eaton
- A
- B
- A
- B
- A
Condition with damage to the anterior horn cell of the spinal cord caused by the poliovirus
Poliomyelitis
HSMN Ib has a defect on which chromosome?
1
The hallmark presentations of this condition are peroneal and distal leg atrophy, weakness, sensory loss and areflexia
Hereditary Sensory Motor Neuropathy
TRUE OR FALSE: ALS affects all of the major muscle groups of the mechanical respiratory system. Oxygen may be used to treat respiratory insufficiency
A. both statements are true
B. both statements are false
C. only the 1st statement is true
D. only the 2nd statement is true
C. only the 1st statement is true
TRUE OR FALSE: A a 12-week moderate resistance exercise program results in strength gains without any notable deleterious effects. If a pt cannot receive tx for 12 weeks, maximal resistance at 6-weeks should be implemented.
A. both statements are true
B. both statements are false
C. only the 1st statement is true
D. only the 2nd statement is true
C. only the 1st statement is true
TRUE OR FALSE: Pts with MND are advised not to exercise to exhaustion. Otherwise, this can produce more muscle damage and dysfunction
A. both statements are true
B. both statements are false
C. only the 1st statement is true
D. only the 2nd statement is true
A. both statements are true
This is a pure UMNL that involves primarily the corticospinal tract. Its initial Sx is LE Spasticity
Progressive Lateral Sclerosis
This condition presents with loss or chromatolysis of motor neurons of the SC and Brainstem. It affects the AHC and presents with distal leg weakness with atrophy.
Progressive Muscular Atrophy
What is the screening tool used to guide diagnosis of ALS?
El Escorial Criteria
Fill in the blanks: Poor Prognosticating Factors for ALS pts
- _____ age at time of onset, > ____ y/o
- _____ dysfunction early in the clinical course of the disease
- Short time period from _____ to _____
- Older; 40-60
- Bulbar and/or pulmonary
- symptom onset to diagnosis