RTK In GF-RAS MAPK

Question 1

RAS?

Answer 1

RA is RAT
S is Sarcoma

Question 2

RAS Properties?

Answer 2

Lipid anchoring
Membrane bound protiein
small G-protein: 170 a.a

Question 3

Inactive whwen

Answer 3

GDP is bound

Question 4

Active when

Answer 4

GTP is bound

Question 5

SOS

Answer 5

Son of sevenless
Proline rich domain
Guanine Exchange Factor
Cytosolic protein

Question 6

Grb2

Answer 6

Growth factor receptor bound protein 2
Adapter protein
SH2 domain

Question 7

Ligand?

Answer 7

EGF

Question 8

Receptor?

Answer 8

Her-2

Question 9

3 Major Kinases?

Answer 9

RAF
MEK
ERK

Question 10

RAF

Answer 10

Serine-threonine kinase
Rapidly accelerated Fibrosarcoma

Question 11

MEK

Answer 11

Tyr-thr Kinase

Question 12

ERK

Answer 12

Ser-Thr Kinas

Question 13

Once RAS is active. binding site for ____ get exposed for?

Answer 13

RAF, and RAF undergoes Phosphorylation

Question 14

RAF phosphorylates the,

Answer 14

MEK

Question 15

MEK phosphorylates?

Answer 15

ERK

Question 16

phosphorylated ERK enters the

Answer 16

nucleus

Question 17

phosphorylated ERK , phosrylates the

Answer 17

ELK
ETS
and ERK doesn’t directly Phosphorylates MYC`

Question 18

After transcription, Myc provides _______ and ________?

Answer 18

Cyclin D and
CDK-4 appears for first, and cell enters to G1 from G0

Question 19

Termination of pathway?

Answer 19

RAF binds to RAS

GAP (NF 1) binds to Arg-residues,

GTPase becomes active

GTP gets hydrolysed