Delta Notch Pathway

Question 1

Delta-Notch signaling pathway?

Answer 1

plays a crucial role in various
developmental processes, particularly in regulating cell fate decisions,
tissue differentiation, and
lateral inhibition during embryogenesis.

Question 2

Delta?

Answer 2

Ligand

Question 3

Notch?

Answer 3

Receptor

Question 4

Delta-Notch signaling is an example of?

Answer 4

Contact signalling (Juxtacrine)

Question 4

Responsible for?

Answer 4

proliferation
Differentiation
Angiogenesis
Myogenesis

Question 5

CSL (CBF1/RBP-Jκ, Suppressor of Hairless, Lag-1) is a ?

Answer 5

transcription factor

Question 5

NICD

Answer 5

Intracellular fragment of the Notch receptor that is released upon activation.

Question 6

binding of Delta to Notch causes a conformational change in the Notch receptor, leading to its ?

Answer 6

cleavage by γ-secretase.

Question 7

The NICD translocates to the?

Answer 7

nucleus

Question 8

In Nucleus, NICD interacts with the ?

Answer 8

CSL transcription factor.

Question 9

This interaction of NICD with CSL, converts CSL ?

Answer 9

from a transcriptional repressor to a transcriptional activator, promoting the expression of target genes.

Question 10

The target genes activated by NICD typically include ?

Answer 10

Hes and Hey family genes

Question 11

Biological functions?

Answer 11

Cell Fate Determination
Lateral Inhibition
Neurogenesis
Vascular Development
Immune Response
maintains tissue homeostasis

Question 12

Dysregulation of the Delta-Notch pathway is associated with various diseases, including:

Answer 12

Cancer
Developmental Disorders
Cardiovascular Diseases