JAK STAT Pathway

Question 1

JAK?

Answer 1

cytosolic and nRTK

Jasus Kinase

or, Just another kinase

Question 2

STAT?

Answer 2

Signal Transducers & Activators of Transcription

Question 3

JAK: 4 main JAK. Name them?

Answer 3

JAK 1
JAK 2
JAK 3
JAK 4

Question 4

7 STAT proteins. Name them?

Answer 4

STAT 1
STAT 2
STAT 3
STAT 4
STAT 5a
STAT 5b
STAT6

Question 5

Ligand for JAK-STAT?

Answer 5

Cytokines or Growth Factor

Question 6

Receptor doesn’t have intrinsic kinase activity, that’s why they rely on?

Answer 6

JAK for signal transduction

Question 7

LIGAND BINDING Induces?

Answer 7

Dimerization / Oligomerization of receptors

Question 8

Close proximity of JAK allow receptors to Phosphorylates each other on?

Answer 8

Tyrosine Residues

Question 9

Phosphorylated tyrosine Residues on receptor act as a?

Answer 9

Docking site for STAT proteins.

Question 10

STAT recruited on Phosphorylated tyrosine via?

Answer 10

SH2 Domain

Question 11

STAT dimer translocates from ?

Answer 11

Cytosol to Nucleus and binds to specific DNA sequence in promoter region k/a Gamma activated sequence (GAS) element via DBD.

Question 12

In Nucleus, STAT act as

Answer 12

Transcription factor

Question 13

Transcription of genes involved in?

Answer 13

Cell Growth
Apoptosis
Immune response
And Differentiation

Question 14

Termination by?

Answer 14

1. Suppressor of Cytokine signalling (SOCS)
2. Protein Inhibitors of Activated STAT (PIAS)
3. Protein Tyrosine Phosphatases (PTPs)

Question 15

SOCS?

Answer 15

Binds to JAK Receptor and Inhibit signalling

Question 16

PTPs?

Answer 16

De-phosphorylates JAK and STATs and Turn off the signal