Receptor Tyrosine Kinase (RTK)

Question 1

RTK Receptor

Answer 1

Integral membrane protein (RTK)
Single Pass
N-Terminal Extracellular
C-terminal: Cytosolic ; Tyrosine Kinase

Question 2

In absence of Ligand, Receptors are

Answer 2

Separated

Question 3

RTK develop the _____ activity

Answer 3

Kinase

Question 4

Receptor Auto-phosporylates?

Its True or False?

Answer 4

True

Question 5

After phosporylation, what happens?

Answer 5

Any cytosolic Protein having SH2 Domain and PTB domain can interacts with RTK.

Question 6

Src Homology 2 binds with specific sequence, that sequence is ___

Answer 6

pYXXZ,
eg : Ptyrosine. Glu. Glu-Ile
where “P” is Phosphotyrosine,
“X” can be any amino acid and
“Z” is usually a bulky hydrophobic or aromatic residue.

Question 7

IRS has?

Answer 7

SH2 domain

Question 8

_______ binds with IRS?

Answer 8

PI3K

Question 9

PI3K Phosporylates?

Answer 9

PIP2

Question 10

PI3K Phosporylates PIP2, and ____ froms?

Answer 10

PIP3

Question 11

PIP3 activates?

Answer 11

PKB or AKT

Question 12

AKT:

Answer 12

Glucokinase
GSK - Inactive
mTOR
Inhibit BAD: cell survival
GLUT on memb. of cells of skeletal muscles

Question 13

mTOR

Answer 13

Mammalian target of Rapamycin (name of city)

Ser-Thr kinase

Question 14

BAD

Answer 14

PRO-APOPTOPIC PROTEIN
p-Bad : Inactive

Question 15

Conversion of PIP3 to PIP2, is done by ?

Answer 15

PTEN (Phosphatase tensin)