RTA/Renal Tubular Defects

Question 1

RTA 1? MOA?

Answer 1

Defect in ability of α intercalated cells to secrete H+=>metabolic acidosis

Question 2

RTA 1 can lead to?

Answer 2

Increased risk of risk for calcium phosphate kidney stones

Question 3

RTA 1 urine?

Answer 3

Distal (type 1), urine pH > 5.5

Question 4

RTA 2? MOA?

Answer 4

Defect in PCT HCO3− reabsorption=> increased 􏰀excretion of HCO3− in urine

Question 5

RTA 2 can lead to?

Answer 5

Increased risk for hypophosphatemic rickets.

Question 6

RTA 4? MOA?

Answer 6

K-ALD=>hypoaldosteronism=>hyperkalemia=>􏰂􏰁NH4+ excretion

Question 7

Generalized reabsorptive defect in PCT?

Answer 7

Fanconi syndrome=>RTA 2

Question 8

Reabsorptive defect in thick ascending loop of Henle. Autosomal recessive?

Answer 8

Bartter syndrome

Question 9

Reabsorptive defect of NaCl in DCT?

Answer 9

Gitelman syndrome

Question 10

Gain of function mutation􏰂􏰀Na+ reabsorption in collecting tubules (􏰀activity of epithelial Na+ channel)?

Answer 10

Liddle syndrome