Renal Pharmacology Flashcards

1
Q

Aliskiren MOA? Use? AE?

A

MOA: Direct Renin Inhibitor (think it Ali’s Renin)=>blocks Angiotensinogen to angiotensin IUSE: HTNAE: Hyperkalemia (No aldosterone)

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2
Q

ACE Inhibitor MOA? Use? Result?

A

MOA: Blocks formation of AT2 and degradation of bradykininUse: Diabetic Nephropathy, CHFResult: Increased AT1, Increased Bradykinin, decreased aldosterone release

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3
Q

ARBs (Losartan)

A

MOA: Block AT1 Receptors; Does not interfere with BradykininUse: Diabetic Nephropathy, CHF

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4
Q

ACE Inhibitor AE?

A

Dry Cough and Angioedema (Bradykinin)!, Hyperkalemia (No aldosterone), Contra in Bilateral renal stenosis=>ARF

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5
Q

ACE Inhibitor (Captopril) MOA? Use? Result?

A

MOA: Blocks formation of AT2 and degradation of bradykinin
Use: Diabetic Nephropathy, CHF=>Result: Increased AT1, Increased Bradykinin, decreased aldosterone release

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6
Q

ACE Inhibitor AE?

A

Dry Cough and Angioedema (Bradykinin)!
Teratogen (Renal) problems,
Increased Creatinine, Hyperkalemia (No aldosterone), Contra in bilateral renal Stenosis=>ARF, “CATCHS cough”

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7
Q

Mannitol MOA? Use?

A

MOA: Osmotic diuretic=>increase urine flow

Use: Rhadbdomyolysis (myoglobinuria)

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8
Q

Acetazolamide MOA? Use?

A

Carbonic anhydrase inhibitor=> decreased HCO3− stores.

Use: High Altitude Sickness

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9
Q

Acetazolamide AE?

A

Hyperchloremic metabolic acidosis, paresthesias=>hypokalemia, Renal Stones

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10
Q

Loop Diuretics MOA? Use?

A

MOA: 1. Sulfonamide loop diuretics. Inhibit cotransport system (Na+/K+/2Cl−)
2. Stimulate PGE release

Use: DOC for HF, cirrhosis, nephrotic syndrome, pulmonary edema

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11
Q

Loop Diuretics AE?

A

Ototoxicity, Hypokalemia, Dehydration, Allergy (sulfa), Nephritis (interstitial), Gout.

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12
Q

Why use Ethacrynic acid?

A

Diuresis in patients allergic to sulfa drugs.

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13
Q

Thiazide MOA?

A

MOA: Inhibit NaCl reabsorption in early DCT 􏰁􏰂diluting capacity of nephron.􏰂 Decreased Ca2+ excretion

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14
Q

Thiazide AE?

A

HyperGLUC

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15
Q

Spironolactone and eplerenone MOA?

A

competitive aldosterone receptor antagonists in cortical collecting tubule

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16
Q

Triamterene, and Amiloride. MOA?

A

Block EnAC

17
Q

SPironolactone AE?

A

Hyperkalemia (can lead to arrhythmias), endocrine effects with spironolactone (e.g., gynecomastia, antiandrogen effects).