RSV...Measles Flashcards

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1
Q

introduction

A

in 3rd world - 900,000 death per year

causes fever, respiratory symptoms & macullopapularl rash (FRM)

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2
Q

pathogenesis and pathology

A

human are the only natural host

  • the virus enter the body trudgen’s respiratory tract where they multiply locally
  • the inf spreads to the regional lymphoid tissues (further multiplication)
  • primary viremia -spread the virus to reticuloendothelial system
  • secondary viremia- shows in the epithelial surface of the body e.g skin, respiratory tract, conjunctiva (focal replication)
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3
Q

measles can replicate in certain lymphocytes, yes or no

A

yes

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4
Q

what is seen in lymphoid tissue throughout the body?

A

multinucleate gains cells with intranuclear inclusions

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5
Q

What occurs during the incubation period (8-12days)

A
PRODORMAL PHASE (2-4days)
virus is present in tears, nasal/troat secretion,urine, blood

ERUPTIVE PHASE- abt 14 (5-8days)days the maculopapular rash will appear and circulating ab becomes detectable

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6
Q

when viremia disappears what happens

A

fever falls

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7
Q

rash develops as a result of

A

interaction btw immune t cell and virus in the small blood vessel

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8
Q

rash last for how long

A

1 week

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9
Q

is CNS involvement common or not

A

yes it is

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10
Q

cns involvement

A

symptomatic encephalitis- 1:1000 cases

rarely recovers from the brain

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11
Q

progressive measles inclusion body encephalitis occurs when?

A

patients is cell mediated immunity defective

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12
Q

clinical findings

A

PRODORMAL PHASE
fever, sneezing,coughing,redness of the eye, running nose, lymphopenia, koplik spots

cough&coryza- intense inflammatory reaction in the mucosa of respiratory tract

conjunctivitis is associated with photophobia

kopek spot- small bluish-white ulceration on the buccal mucosa opposite the lower molar
-rash begins on the head-chest-trunk-limbs
otits media
pneumonia
pulmonary complications
giant cell pneumonia in defective immune cells
cns involvement is serious

subacute sclerosing pan encephalitis- rare complication ; it begins 5-15 years after measles inf and causes progressive mental deorientation
involuntary movements
muscular rigidity
coma
it is usually fatal within 1-3 years after onset

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13
Q

koplik spot contains

A

giant cells and viral antigen

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14
Q

light pink discreet maculopapules coalesce to form?

A

blotches becoming brownish in 5-10days

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15
Q

in partially immune person, modified measles occurs as?

A

prodromal illnesss without koplik spot

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16
Q

most common complication of measles

A

otitis media

17
Q

most common life threatening complication of measles

A

pneumonia- secondary bacteria inf

18
Q

90% of measles death is due to?

A

pulmonary complications

19
Q

giant cell pneumonia occurs in?

A

children and adult with defective immune cells

20
Q

the most serious complication of measles

A

CNS involvement

21
Q

late complication of measles inf

A

subacute sclerosis panencephalitis

22
Q

immunity

A

only one antigenic type of measles occurs and it gives life long immunity

local inflammation causes prodromal illness
specific cell mediated immunity develops the rashes