Epstein Barr Virus (EBV) C2 Flashcards

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1
Q

Burkitt

A

Unusual lymphoma

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2
Q

Ebv affect which lymphocyte?

A

B lymphocyte

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3
Q

Ebv infection leads to?

A

Latency
Periodic reactivation
Life long persistence

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4
Q

Source of Ebv infection?

A

Saliva

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5
Q

EBV

A

Occur in children and infants
Humans are the only natural host

Oropharyngeal secretion
Primary inf
Intermittent

It is not highly contagious

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6
Q

Mode of transmission ?

A

Intimate oral contact (kissing)

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7
Q

Another name for EBV

A

Kissing disease

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8
Q

Ebv replication takes place where

A

In epithelial cells and encodes many proteins

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9
Q

EBV Glycoproteins ?

A

Gp350/220 - attachment to CD21

and Gp85-membrane fusion

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10
Q

Cells that expresses CD21

A

Mature B cell
Stratified squamous epithelium e.g salivary gland
Oropharynx
Ectocervix

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11
Q

Pathogenesia of EBV?

A

Ebv enters- the pharyngeal epithelial cells- multiplies locally-bloodstream-infect b lymphocyte

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12
Q

Two types of changes in B cells?

A

One type- virus become latent inside B cells

Indifinite growth of B cell
Becomes immortalised/transformed
Produces igm, G, A
Igm contains heterophile antibodies 
Virus antigen express on the surface 
B cell proliferation 
Intermittent reactivation of latent EBV leads to proliferation of infected B cell

Second type- virus lyses the B cell and cause cell death& release of nature progeny virions

Atypical lymphocyte sewn in blood smear
Most immunodeficiency patients have lymphoma containing EBV
X-linked lymphoproliferative syndrome or Duncan is associated with susceptibility to EBV

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13
Q

Clinical features of EBV?

A

Infectious mononucleosis / glandular fever
Primary inf seen in 15-25 years age group

Incubation period 30-50 days
Onset with- sore throat
Cervical lymphadenopathy 
Fevered
Pharyngitis with greyish 
 membrane
Intermittent fever $ sweating- over 2weeks

Transient morbiliform rash
Hepatitis - subclinical level
Maculopapular rash - may follow ampicillin administration

Airway obstruction due to lymphoid enlargement and edema

Neurological- meningitis

Encpahalitis
Gillian barre syndrome

  1. EBV & malignancies
    A. Burkitt lymphoma
    B. EBV -associated nasopharyngeal
    carcinoma
  2. EBV in HIV and immunocompromised- hairy leukoplakia (white grey lesion on tongue)
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14
Q

Lab diagnosis of EBV?

A

Leukopenia
Leukocytosis
Abnormal mononuclear cells(basophillic& kidney shaped nuclei)

Paul bunn test - standard diagnosis

Heterophile ab- agglutinates sheep red cells

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15
Q

Treatment of EBV

A

Acyclovir

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