Cytomegalovirus (CMV) Flashcards
CMV?
Aka salivarys gland virus
Causes inf in human $ animals
Largest virus in herpes virus family
Strict host specificity
Neonate& immunodeficient- severe disseminated inf
Children & adult- asymptomatic or self limited Inf
CMV is characterised by?
Enlarged infected cells
Intranucllear inclusions giving a owl eye appearance
Goodpasture is termed?
Cytomegalia
CMV replicates in ?
Epithelial cells-
Salivary glands
Renal
Respiratory tract
CMV is sensitive nd stable in?
Freezing & thawing
Virus shed in urine is stable at 4oc for days
Pathogenesis of CMV?
Persist for life in host
Prolonged latency leading to occasional reactivation (endogenous/exogenous)
Shed in semen, urine, saliva, semen, breast milk, cervical fluid
Clinical disease of CMV may be caused by?
- Intrauterine inf- maternal viremia during pregnancy may lead to disease in the fetus thru trans placental inf with ugh viremic load
- Prenatal inf- infected maternal genital secretion or breast feeding
- Postnatal inf- saliva shared by kissing
Semen
Blood transfusion
Donated organ
Clinical features (causes)?
- Congenital CMV inf- ass in 95% babies
15%_ sensorineural deafness
Intellectual impairment later
Extremely abundant virus in urine
5%- Di c inclusion body disease
- Mononucleosis - CMV from blood traansfusion
Heterophile ab is not found - Inf in immunocompromised patient- may develop symptoms as the result of primary or recurrent CMV inf
Pneumonitis- high mortality in bone marrow allograft recipients
Oesophagitis/colitis (5-10% AIDS patients)
Lab diagnosis in CMV?
Urine Saliva Peripheral blood Biopsy tissue Broncho- alveolar lavage fluid
Neonate- urine is taken in 1st 2 weeks of life for diagnosis of congenital inf
CMV In cell culture
Treatment of CMV?
Ganciclovir- CMV disease
Foscarnet- alternative for ganciclovir
CMV vaccine is not available
Acyclovir is not effective
Prevention of CMV ?
Screening blood and organ donor
Administration of CMV ig to prevent viral inf
