Rotenone

Question 1

Name 2 plant sources of rotenone.

Answer 1

Derris elliptica and jicama seeds.

Question 2

Fill in the blanks:
Uses of rotenone include: use in home and garden,
for the treatment of ____/____ for pets and horses, as a piscicide, and for the treatment of ____ on chickens.

Answer 2

lice/ticks

mites on chickens.

Question 3

Rotenone may also be used as a dust for berries and fruits to control ______.

Answer 3

aphids

Question 4

Concerning rotenone toxicity:
Rotenone is very toxic to fish and cold-blooded animals and
it is a piscicidal at __-__ppb.

Answer 4

20-40ppb

Question 5

Which of the following statement s is TRUE:
A. Generally low toxicity for mammals with cats being more sensitive.
B. Generally low toxicity for mammals with dogs being more sensitive.
C. Generally low toxicity for mammals with pigs being more sensitive.
D. Generally low toxicity for mammals with horses being more sensitive.

Answer 5

C is true. Pigs are more sensitive.

Question 6

T/F concerning rotenone toxicokinetics:

Fats and oils increase absorption therefore ingestion is more toxic than inhalation.

Answer 6

False.

While fats and oils do increase absorption, INHALATION is more toxic than ingestion.

Question 7

Of the following statements which ones are TRUE:
A. Fish convert rotenone to non-toxic metabolites.
B. Fish convert rotenone to toxic metabolites.
C. Mammals convert rotenone to non-toxic metabolites.
D. Mammals convert rotenone to toxic metabolites.
E. Insects convert rotenone to non-toxic metabolites.
F. Insects convert rotenone to toxic metabolites.

Answer 7

B, C, and F are true.

Question 8

Elimination of rotenone occurs within __ hours in the feces.

Answer 8

24 hours.

Question 9

Concerning rotenone MoA.
Rotenone prevents NADH from being oxidized to NAD. This interferes with ATP production by the mitochondria. When there are excessive levels of _______ ________ _______ made by the mitochondria, cell death by apoptosis will occur.

Answer 9

reactive oxygen species

Question 10

When it comes into contact with nerve axons, rotenone has an __________ effect.

Answer 10

anesthetic

Question 11

Rotenone has specific sets of CS depending upon the route of expose. That being said, there are 2 general CS that predominate. What are they?

Answer 11

Depression and convulsions.

Question 12

Antemortem lab findings may include all of the following EXCEPT:
A. hyperglycemia
B. hypoxemia
C. hypercapnea
D. compound found in stomach contents, urine, feces

Answer 12

A. You would not find hyperglycemia, you would find HYPOglycemia.