Misc. Flashcards

1
Q

In mammals, toxicity amount is described using…

A

LD 50 in mg/kg BW.

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2
Q

In birds, toxicity amount is described using…

A

LC50 mg/kg feed.

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3
Q

In fish, toxicity amount is described using…

A

LC50 mg/L H2O.

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4
Q

Acute toxicity occurs in what time frame?

A

24 hours.

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5
Q

Subacute toxicity occurs within what time frame?

A

1-30 days.

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6
Q

Subchronic toxicity occurs between what time frame?

A

30-90 days.

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7
Q

Chronic toxicity would be described as occurring over what amount of time?

A

3 months or more.

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8
Q

What is chronicity factor?

A

It is the ratio between acute LD50 and chronic LD50.

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9
Q

Extremely toxic = ?

A

1mg/kg or less.

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10
Q

Highly toxic = ?

A

1 - 50mg/kg.

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11
Q

Moderately toxic = ?

A

50 - 500mg/kg.

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12
Q

Slightly toxic = ?

A

0.5 - 5g/kg

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13
Q

Practically non-toxic = ?

A

5 - 15 g/kg.

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14
Q

Relatively harmless = ?

A

> 15g/kg

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15
Q

What is the highest/largest dose which does not result in undesirable or toxic alterations?

A

Highest non-toxic dose (HNTD)

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16
Q

What is the maximum tolerated dose (MTD)?

A

It’s similar to the highest non-toxic dose.

17
Q

What is the Toxic Dose Low (TDL)?

A

Lowest dose that produces toxic alterations and administering twice this dose will NOT cause death.

18
Q

What is Toxic Dose High (TDH)?

A

Dose which produces toxic alterations and administering twice this dose WILL cause death.

19
Q

Describe the no-effect level (max non-toxic level).

A

Amount of a chemical that can be ingested w/o causing any deaths, illness, or toxic alterations in any animal for a stated period. (usually 90 days to 2 years, depending on the species)

20
Q

What is the highest dose that does not cause any deaths?

A

LD-0

21
Q

What is the dose that kills 50% of animals in a group?

A

LD 50

22
Q

What is the lowest dose that kills all the animals?

A

LD 100