Amitraz

Question 1

Foramidine insecticide has what effect on mites and ticks.
A. Sterilizes the adults.
B. Kills the eggs.
C. Disrupts adult metabolism.
D. Paralyzes the mouth parts.

Answer 1

D. Paralyzes the mouth parts.

Question 2

Why would an animal being treated for generalized demodicosis be more susceptible to the toxic effects of that therapy.

Answer 2

Because they are already immunosuppressed.

Question 3

T/F. Amitraz is safe for swine, cattle and cats.

Answer 3

False. It is safe for swine, cattle, and dogs. “Relatively contraindicated” for cats or horses.

Question 4

What is the MoA of Amitraz?

Answer 4

It is an alpha-2 adrenergic agonist in the CNS.

Also has weak A-1 agonist activity and weak MAO inhibition.

Question 5

All of the following increase toxicity of Amitraz except:
A. Advanced age.
B. Illness and debilitation.
C. Giant breeds
D. Stress.
E. Sympathomimetic amines.

Answer 5

C. Is not true. Being a toy breed can increase toxicity.

Question 6

The acute oral LD50 dose of Amitraz for dogs is?

Answer 6

About 250mg/kg.

Question 7

T/F. Amitraz is readily absorbed orally, can also be absorbed topically, but is not absorbed through inhalation.

Answer 7

False. It is absorbed through inhalation as well.

Question 8

Amitraz has an elimination half life of:
A. 5 hours
B. 24 hours
C. 48 hours
D. 72 hours.

Answer 8

B. 24 hours. It reaches peak plasma concentrations after 5 hours.

Question 9

T/F. Amitraz is well distributed throughout the body, including the CNS.

Answer 9

True.

Question 10

The most common CS of Amitraz toxicosis is _____ ______ and may last for 24-72 hours.

Answer 10

transient sedation

Question 11

Hyperglycemia can be seen with Amitraz toxicosis because of which mechanism?

Answer 11

Alpha-2 inhibition of insulin release.

Question 12

The most significant ddx for Amitraz toxicosis are other CNS __________.

Answer 12

depressants.

Ethanol, ivermectin, ethylene glycol, Mary Jane.

Question 13

T/F. Tissue can be analyzed to determine toxic levels.

Answer 13

False. Tissue analysis can only determine exposure. Toxic levels have not been determined.

Question 14

T/F. Treatment can only be achieved through washing the skin, inducing vomiting, and then supportive care.

Answer 14

Wrong!. This one has an antidote! Alpha-2 antagonists such as Yohimbine and Atipamizole can be used.

Question 15

The Amitraz antidote Yohimbine has short action and has (fewer/more) cardiorespiratory effects than Atipamezole.

Answer 15

more

Question 16

The prognosis for Amitraz toxicosis is:
A. Good
B. Poor
C. Gonna die.

Answer 16

A. “Pretty good actually”