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Hugh's MD1 Metabolism > Role of the GIT in Obesity > Flashcards

Role of the GIT in Obesity Flashcards

1
Q

What is the pattern of ghrelin secretion?

A

Cyclical - rises before meals and drops after

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2
Q

What other therapeutic does oxyntomodulin have a synergic effect with?

A

PYY

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3
Q

Which cells are the main producers of CCK?

A

I cells of the small intestine

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4
Q

Why can’t CCK work as a therapeutic?

A

Though it lowers meal size, the number of meals increase therefore the overall calorie consumption is high

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5
Q

What is the bodies’ response to weight loss in the long term?

A

Attempts to defend the original weight

  • increase ghrelin
  • decrease amylin, CCK and PYY
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6
Q

Where is insulin-like peptide 5 produced in the greatest quantity?

A

The colon

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8
Q

Does ghrelin signal hunger or satiety?

A

Hunger

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8
Q

What is liraglutide?

A

Long acting GLP-1 analogue

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9
Q

What receptor does oxyntomodulin act through?

A

The GLP-1 receptor

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10
Q

Which cells of the arcuate nucleus produce the satiety peptides?

A

The POMC cells

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10
Q

What was the effect of GLP-1 treatment in humans?

A

Reduced hunger

Increased the feeling of fullness

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11
Q

Is insulin-like peptide 5 a hunger or satiety hormone?

A

Hunger

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12
Q

What is the drawback with PYY therapy?

A

Causes nausea

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13
Q

Which part of the GIT produces the greatest amount of ghrelin?

A

The stomach

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14
Q

Is CCK a hunger or satiety signal?

A

Satiety

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15
Q

What is the mechanism of action of GIP?

A

Promotes triglyceride clearance from the circulation by activating lipoprotein lipase

16
Q

What is the effect of PYY?

A

Reduced food intake

17
Q

What are the hunger peptides produced by the arcuate nucleus?

A

NPY

AGRP

18
Q

Which peptide does ghrelin act through in the arcuate nucleus?

A

NPY

20
Q

What are the satiety peptides produced by the arcuate nucleus?

A

CART

alpha MSH

21
Q

What is the effect of the microbiota on obesity?

A

Increase FA metabolism and storage of calories in fat

22
Q

What is the effect of oxyntomodulin?

A

Reduce food intake and increase energy expenditure

23
Q

What is the name of the master controller of hunger and satiety in the hypothalamus?

A

The arcuate nucleus

Hugh's MD1 Metabolism (15 decks)

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