Mitochondria Flashcards
What is fatty acids conversion into acetyl-CoA called?
Beta-oxidation
On which mitochondrial membrane does oxidative phosphorylation occur?
The inner membrane
What happens to mitochondria over time?
They get damaged by ROS
Are mitochondria maternally or paternally derived?
Maternally
Uncoupling of oxidative phosphorylation produces what?
Heat
What stimulates release of FAs from adipose tissue?
Flight or fight
Glucagon
Which respiratory complex is entirely encoded by nuclear DNA?
II
How is ATP produced at the end of the oxidative phosphorylation?
Mechanical winding of beta-subunit in ATP synthase
What is the function of the malate-aspartate shuttle?
Transfers the reducing power of NADH from cytosol to mitochondria for oxidative phosphorylation
What energy molecules does the Kreb cycle produce each turn?
3NADH
1FADH2
1ATP
What are ragged red fibres?
A hallmark of mitochondrial diseases
What are the transporters for pyruvate in the mitochondria inner membrane?
Antiport
Symport
What do statins do to the mitochondria?
Reduce Q10 production
How many respiratory complexes are there?
4
How are ROS created during the oxidative phosphorylation process?
Electrons leak from the membrane
