Robbins Chapter 13 - WBC Morphology

Question 1

Morphologic changes in neutrophils that often accompany leukocytosis .

Answer 1

Toxic granulations, Dohle bodies (dilated ER) , cytoplasmic vacuoles

Question 2

What is this describing - 
Nodes are (painful) swollen, gray-red, and engorged.  Large reactive germinal centers with numerous mitotic figures. Macrophages often contain particulate debris derived from dead bacteria or necrotic cells.

Answer 2

Acute Nonspecific Lymphadenitis

Question 3

The name of the macrophages containing nuclear debris of B cells that are interspersed between the germinal B centers.

Answer 3

Tingible body macrophages

Question 4

A person has one of these three things - Rheumatoid arthritis, toxoplasmosis, early HIV.
What type of hyperplasia are these stimuli for?

Answer 4

Three stimuli that cause Follicular Hyperplasia - round, oblong germinal centers surrounded by collar of small resting naive B cells (mantle zone)

Question 5

Name the type of hyperplasia-

1. Dark zone containing proliferating blastlike B cells (centroblasts)
2. Light zone containing B cells with irregular or cleaved nuclear contours

Answer 5

Follicular hyperplasia - a reactive follicle surrounding mantle zone

Question 6

A person has a viral infection (i.e. infectious mono) - what type of hyperplasia is this a stimulus for?

Answer 6

Stimulus for T-cell mediated immune responses that cause Paracortical Hyperplasia (expanded T-cell zones)

Question 7

Name the type of hyperplasia - increased number and size of cells that line the lymphatic sinusoids. Lining lymphatic endothelial cells is markedly hypertrophied and macrophages increased = expansion and distension of sinuses.
Possible in nodes draining cancers (i.e. breast cancer)

Answer 7

Sinus histiocytosis (reticular hyperplasia)