Robbins Chapter 13 - WBC Diseases and Spleen/Thymus

Question 1

Platelets, RBC, and Leukocytes - origin, transport, and residency

Answer 1

Platelets and RBC - originate in marrow, live in blood

Leukocytes (monocytes, granulocytes, lymphocytes) - originate in marrow, live in TISSUE

Question 2

name for a juvenile granulocyte. Major feature is an indented nucleus

Answer 2

metamyelocyte

Question 3

Lymphocyte markers:

T-helper, T-cytotoxic, B-Cell, NK-cell

Answer 3

T-helper - CD4
T-cytotoxic - CD4
B-Cell - CD19
NK-cell - CD56/16

Question 4

If alkylating agents or anti-cancer agents are used, think what broad type of WBC disorder?

Answer 4

Leukopenia - agranulocytosis

Question 5

Ulcerating lesions of gingiva, floor of mouth, buccal mucosa, pharynx, or elsewhere in oral cavity are characteristic of what?

Answer 5

Infection as the consequence of agranulocytosis that causes leukopenia.

Question 6

What compensatory change occurs in marrow due to leukopenia?

Answer 6

hypercellularity