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Hematology and Oncology > Chapter 14 - RBC CIS > Flashcards

Chapter 14 - RBC CIS Flashcards

1
Q

Low MCV and high RDW is ___ anemia until proven otherwise

A

iron deficiency anemia (chronic blood loss anemia)

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2
Q

Chronic Blood Loss Anemia is most likely due to

A

colonic carcinoma

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3
Q

Normal RCW (red cell distribution width)

A

11.5-14.5

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4
Q

Normal Hgb

A

about 15

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5
Q

Normal Hct

A

about 45

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6
Q

normal platelet count

A

150,000 - 450,000

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7
Q

Ferritin is 10ug/L. Ferritin deficiency causes what? Why?

A

Chronic blood loss over time causes ferritin deficiency. Ferritin is for iron storage

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8
Q

Define Pica

A

People with (iron deficiency) anemia who eat anything – especially dirt or ice.

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9
Q

Normal MCV. What’s above/below?

A

80-100
Above=megaloblastic
Below = microcytic

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10
Q

Any disorder of ineffective erythropoiesis that starts as normocytic, can COT to what?

A

Microcytic

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11
Q

Normal MCHC

A

31-37%

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12
Q

Oral iron supplementation given to a person with chronic blood loss anemia prior to surgery for colon carcinoma. Reticulocytosis on PS noted in about one week. Why?

A

Person had IDA - pt is receiving oral iron and the marrow responds with reticulocytes (RDW will probably increase even more).

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13
Q

Will ACD repsond to Fe?

A

Probably not.

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14
Q

What type of anemia is asosciated with membrane defect?

A

extravascular hemolytic anemia.

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15
Q

RF+ and erosive, inflammatory arthritis of hands and elbow. WBC elevated, left shift, thrombocytosis. Hgb is 12 (so Hct is ~36) RBC has normocytic, normochromic anemia. What is this?

A

Anemia of Chronic Disease

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16
Q

Episodic manifestations of hemolysis. Acutely ill with severe anmeia. Precipitated bu infeciton or drugs

A

G6PD deficiency

17
Q

High serum ferritin seen in

A

ACD

18
Q

Significant thrombocytopenia, PS shows leukoerythroblastosis. Marrow transplant 10 year ago during radiation for papillary carcinoma of the thyroid. Presents with normocytic, normochromic anemia.

A

MDS or MPD

19
Q

Parkinson-like neuro symptoms. Moderate leukopenia with MCV of 110 (high) and PS multiple hypersegmented PMNs (means megaloblastic). Labs indicate elevated homocysteine and methymalonate. Most likely?

A

Pernicious Anemia

20
Q

Hypersegmented PMNs means

A

megaloblastic

21
Q

Labs for homocysteine and methymalonate. in folate deficiency.

A

Elevated homocyteine, but not methymalonate.

22
Q

24 year old woman with lethargy and low libido. Basophilic stippling is identified in some erythrocytes. Serum ferritin increased significantly. HbA2 is 7% (elevated) and small quantity of HbF detected upon electrophoresis. Most likely?

A

Beta-thalassemia minor (younger in life)

23
Q

HbF in beta-thalassemia major v. minor

A

increased in major, not much in minor.

24
Q

excess of beta globin chains form Beta 4 tetramers known, seen in newborns.
excess gamma chains form gamma 4 tetramers - this is?

A

HbH = severe microcytic anemia

Hydrops fetalis, Hemoglobin barts = death

25
Q

Immunohemolytic anemia:

IgM antibody

A

Cold agglutinin(i.e. mono or mycoplasma infection)

26
Q

Warm antibody associated with…

A

SLE, diret coombs IGG

27
Q

Most common hematologic manifestation of HIV

A

thrombocytopenia

28
Q
  1. A 37 year old white female. 12gm/dl Hgb, MCV of 75fl and RDW of 16. Plts 30,000. Sparse petechiae, weak, pale pallor, pale conjuctivae, ferritin low. Most likely which of the following?
A

Primary Chronic ITP

29
Q

Modestly increased marrow megakaryocytes. PS has abnormally large platelets.

A

TTP

30
Q

Target cells and spherocytes

A

Thalassemias

31
Q

Haptoglobin decrease indicates

A

Hemolytic anemia (both intravascualr or extravascular)

32
Q

6 year old male hx of easy bruising with casual physical contact. PT normal, PTT elevated. What is most likely?

A

Hemophilia A and B

33
Q

IDA v. ACD levels:

  • Free iron
  • Transferrin saturation
  • TIBC
  • Serum ferritin
  • Hepcidin
A
  • Free iron - low, low
  • Transferrin saturation - low, high
  • TIBC - high, low
  • Serum ferritin - low, high
  • Hepcidin - low, high
34
Q

Low plt count, PTT/PT prolonged, fibrin split products identified, microangiopathic fragmented red cell forms.

A

DIC

35
Q

low MCV, low Hct/Hg. IDA. PBS=

A

hypochromasia

36
Q

nucleated RBC suggest?

A

hemolysis or a disease infiltrating and replacing bone marrow (hymolysis=hyperBr)

37
Q

anisocytosis and poikilocytosis

A

alpha thalasemia

38
Q

high HCt v low Hct

A 
high = polycythemia
low = anemia

Hematology and Oncology (18 decks)

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