RNU Flashcards
What type of drug is the Combined Pill
Oestrogen +
Progestins
What is the mechanism of action of the combined pill
• Oestrogen and Progesterone causes negative
feedback to the anterior pituitary - thus inhibit LH/
FSH release, which prevents release of the oocyte.
• Also thickens cervical mucus and endometrial lining
to prevent sperm reaching the egg.
• Prevent proliferation of stratum functionalis, making
it incompatible for implantation.
What is the Combined Pill used for?
Contraception
What class of drug is the mini pill?
Continuous
Progestins
What is the mechanism of action of the mini pill
• Progesterone-only pill to be taken everyday at the
same time.
• Thickens cervical mucus, prevent sperm reaching
egg.
What is the mini pill used for
Contraception
What class of drug is Furosemide?
Loop Diuretic
What is the mechanism of action of Furosemide?
Inhibits the action of the NK2CL transporter in the
ascending limb of the loop of Henle. Loop diuretics
are the most powerful diuretics
What is Furosemide used to treat?
Pulmonary Oedema
Hypertension
Hypercalcaemia
Renal Failure/CKD
What class of drug is Bendroflumethiazide?
Thiazide Diuretics
What is the mechanism of action of Bendroflumethiazide?
They act on the DCT inhibiting the Na+/Cl-
transporter, causing natriuresis (sodium excretion)
What is Bendroflumethiazide used to treat?
Hypertension
Hypercalcuria (kidney stones)
Mild heart failure
Nephrogenic Diabetes Insipidus
What class of drug is Amiloride
K+ Sparing Diuretics
What is the mechanism of action of Amiloride
Directly blocks ENaC transports on the principal cells of the DCT. Results in Na+ secretion and K+ retention
What is Amiloride used to treat?
Hypokalaemia
Hypertension
