RNA viruses orthomyxoviruses & paramyxoviruses Flashcards
Y2C1 1 question will be asked
Pox viruses
___virus(GRI-90)
______virus
____virus
______virus(molloscum Contagiosum Virus)
____virus(orf virus)
_____virus(vaccina virus)
fill blanks w/ given words below
cowpox
monkeypox
parapox
orthopox
mollusvipox
variola
cowpox virus
monkeypox virus
variola virus
molluscvipoxvirus
parapoxvirus
orthopoxvirus
orthomyxoviridae
nucleaocapsid of____symmetry occurs in 8 segments
composed of nucleoprotein enclosing a segmented____genome
_____polymerase complex
___RNA genome
helical
segmented RNA
RNA complex
-ssRNA genome
orthomyxoviridae:classification
_____viruses
______orthomyxoviruses
Influenza A,B,C
Tick-borne
Influenza types
Type A
multi____
most____group
Type B
seen in____
Type C
seen in____&___
multi species
virtulent
humans
humans&swine
Influenza A&B
Type A doesn’t share antigens w/ Influenza___
many sub-types
all of which share related_____&____proteins
but differ in_____&_____
mainly seen in____ but in mammals including____
Influenza B
nucleo&matric proteins
hemagglutinin & neuraminidase
birds
humans
Influenza A&B
differ in____&____
hemagglutinin and neuraminidase
Antigens
2 types
____specific
____specific
Type specific
subtype specific
Type specific antigens
____&____protein
nucleo&matrix protein
Subtype specific antigens
_____&_____
hemagglutinin&neuraminidase
Hemagglutinin
H___-___
sites for attachment to receptors to infect___cells(___Acid on epithelial cells)
H1-H15
sialic acid
host cells
Neuraminidase
remove neuraminic acid from___and release from cell
mucin
Antigenic drifts in__&___proteins may result in epidemics
H and N proteins
Influenza C
distinct genus
only 7____segments
single_____
envelope made of_____
fusion protein&____
no shared antigens w/ ınfluenza__&__
no significant disease except some___
RNA
envelope
glycoprotein
protein&esterase
A&B
children
Pathogenesis & Immunity
After Influenza_____bacterial infection can occur which can be fatal
secondary
Influenza:clinical features
confused with___
abrupt onset of___
sore____
nonproductive___
myalgia
headache&malaise
cold
fever
throat
cough
Cold vs flu
Flu is caused by___viruses only
cold caused by common viruses
Influenza
Influenza:animal transmission
Virus in_____secretions&_____
sperad by____,shared____&____
respiratory secretion&feces
aerosol
shared drinking water
fomites
Paramyxoviridae
originally under orthomyxoviridae but differences in_____properities&____strategies
genomic properities&replication strategies
Paramyxoviruses
very fragile____envelope
non-segmented______genome
_____&____symmetry but pleomorphic
linear RNA
spherical,helical
parainfluenza virus
common human____pathogens
___agent
_____virus
morphology:______,____morphic
5 serotypes:_______
no common group____
closely related to____virus
respiratory pathogen
croup agent
-ssRNA virus
enveloped,pleomorphic
1,2,3,4a and 4b
antigen
mumps virus
parainfluenza:clinical features
___most common manifestation
___chiolitis
____monia
Flu-like______
croup
bronchiloliris
pheumonia
tracheobronchitis
Parainfluenza:transmission
by___or____contact
virus disseminates locally in___epithelial cells of_____mucosa
droplets or direct
ciliated
respiratory
Respiratory syncytial virus(RSV)
____virus
belong to genus_____virus of paramyxovirus family
may be classified into subgroups A&B by____clonal sera
causes a sizable____each year
pheumovirus
monoclonal sera
epidemic
Respiratory syncytial virus(RSV):symptoms
mild upper____disease
life-threatening lower_____tract illness in infants and young children
respiratory
Respiratory syncytial virus(RSV):epidemiology & prevention
RSV____can be used to protect infants at risk of severe RSV disease
aerosolised____can be used for infants w/ severe infection & those at risk of severe disease
immunoglobulin
ribavirin
Mumpus virus
causes___
painful enlargement of____glands particularly____glands
most infections occur at winter and spring
many infections are____
rarely occurs today due to vaccination
mumps
salivary&parotid glands
subclinical
Mumps virus:clinical features
___spread
Infectious from 1 to 2 days before____and 5 days after
Incubation is___to___days
prodrome of___,____,___pain and malaise
followed by swelling and pain in____glands
obliteration of angle of____
respiratory
symptoms
14 to 21 days
fever,headache,muscle pain
parotid glands
jaw
Mumps virus:vaccine
weakened___
as part of MMR vaccine which protects aganist___,____&____
given by____injection
virus
measles,mumps&rubella
subcutaneous
Measles virus
member of_____virus in family paramyxoviridae
worldwide, epidemics were common before_____
one of most_____of all viruses
morbilivirus
vaccination
infectious
Measles virus:clinical features
Transmission:direct____contact
incubation:2____
rash evolves from face to trunk to extremities
fever and three Cs which are ?
____spots
droplet contact
weeks
cough,coryza and conjunctivitis
koplik spots
koplik spots:little sugary spots on mucosa next to molar teeth
Measles virus:clinical features
complications are common in____and____
malnutrition esp____deficiency is a major cause of mortality
young kids and adults
vitamin A
