RNA viruses orthomyxoviruses & paramyxoviruses

Question 1

Pox viruses

___virus(GRI-90)
______virus
____virus
______virus(molloscum Contagiosum Virus)
____virus(orf virus)
_____virus(vaccina virus)

fill blanks w/ given words below

cowpox
monkeypox
parapox
orthopox
mollusvipox
variola

Answer 1

cowpox virus
monkeypox virus
variola virus
molluscvipoxvirus
parapoxvirus
orthopoxvirus

Question 2

orthomyxoviridae

nucleaocapsid of____symmetry occurs in 8 segments
composed of nucleoprotein enclosing a segmented____genome
_____polymerase complex
___RNA genome

Answer 2

helical
segmented RNA
RNA complex
-ssRNA genome

Question 3

orthomyxoviridae:classification

_____viruses
______orthomyxoviruses

Answer 3

Influenza A,B,C
Tick-borne

Question 4

Influenza types

Type A
multi____
most____group
Type B
seen in____
Type C
seen in____&___

Answer 4

multi species
virtulent
humans
humans&swine

Question 5

Influenza A&B

Type A doesn’t share antigens w/ Influenza___
many sub-types
all of which share related_____&____proteins
but differ in_____&_____
mainly seen in____ but in mammals including____

Answer 5

Influenza B
nucleo&matric proteins
hemagglutinin & neuraminidase
birds
humans

Question 6

Influenza A&B

differ in____&____

Answer 6

hemagglutinin and neuraminidase

Question 7

Antigens

2 types
____specific
____specific

Answer 7

Type specific
subtype specific

Question 8

Type specific antigens

____&____protein

Answer 8

nucleo&matrix protein

Question 9

Subtype specific antigens

_____&_____

Answer 9

hemagglutinin&neuraminidase

Question 10

Hemagglutinin

H___-___
sites for attachment to receptors to infect___cells(___Acid on epithelial cells)

Answer 10

H1-H15
sialic acid
host cells

Question 11

Neuraminidase

remove neuraminic acid from___and release from cell

Answer 11

mucin

Question 12

Antigenic drifts in__&___proteins may result in epidemics

Answer 12

H and N proteins

Question 13

Influenza C

distinct genus
only 7____segments
single_____
envelope made of_____
fusion protein&____
no shared antigens w/ ınfluenza__&__
no significant disease except some___

Answer 13

RNA
envelope
glycoprotein
protein&esterase
A&B
children

Question 14

Pathogenesis & Immunity

After Influenza_____bacterial infection can occur which can be fatal

Answer 14

secondary

Question 15

Influenza:clinical features

confused with___
abrupt onset of___
sore____
nonproductive___
myalgia
headache&malaise

Answer 15

cold
fever
throat
cough

Question 16

Cold vs flu

Flu is caused by___viruses only
cold caused by common viruses

Answer 16

Influenza

Question 17

Influenza:animal transmission

Virus in_____secretions&_____
sperad by____,shared____&____

Answer 17

respiratory secretion&feces
aerosol
shared drinking water
fomites

Question 18

Paramyxoviridae

originally under orthomyxoviridae but differences in_____properities&____strategies

Answer 18

genomic properities&replication strategies

Question 19

Paramyxoviruses

very fragile____envelope
non-segmented______genome
_____&____symmetry but pleomorphic

Answer 19

linear RNA
spherical,helical

Question 20

parainfluenza virus

common human____pathogens
___agent
_____virus
morphology:______,____morphic
5 serotypes:_______
no common group____
closely related to____virus

Answer 20

respiratory pathogen
croup agent
-ssRNA virus
enveloped,pleomorphic
1,2,3,4a and 4b
antigen
mumps virus

Question 21

parainfluenza:clinical features

___most common manifestation
___chiolitis
____monia
Flu-like______

Answer 21

croup
bronchiloliris
pheumonia
tracheobronchitis

Question 22

Parainfluenza:transmission

by___or____contact
virus disseminates locally in___epithelial cells of_____mucosa

Answer 22

droplets or direct
ciliated
respiratory

Question 23

Respiratory syncytial virus(RSV)

____virus
belong to genus_____virus of paramyxovirus family
may be classified into subgroups A&B by____clonal sera
causes a sizable____each year

Answer 23

pheumovirus
monoclonal sera
epidemic

Question 24

Respiratory syncytial virus(RSV):symptoms

mild upper____disease
life-threatening lower_____tract illness in infants and young children

Answer 24

respiratory

Question 25

# Respiratory syncytial virus(RSV):epidemiology & prevention RSV____can be used to protect infants at risk of severe RSV disease aerosolised____can be used for infants w/ severe infection & those at risk of severe disease

Answer 25

immunoglobulin ribavirin

Question 26

# Mumpus virus causes___ painful enlargement of____glands particularly____glands most infections occur at winter and spring many infections are____ rarely occurs today due to vaccination

Answer 26

mumps salivary&parotid glands subclinical

Question 27

# Mumps virus:clinical features ___spread Infectious from 1 to 2 days before____and 5 days after Incubation is___to___days prodrome of___,____,___pain and malaise followed by swelling and pain in____glands obliteration of angle of____

Answer 27

respiratory symptoms 14 to 21 days fever,headache,muscle pain parotid glands jaw

Question 28

# Mumps virus:vaccine weakened___ as part of MMR vaccine which protects aganist___,____&____ given by____injection

Answer 28

virus measles,mumps&rubella subcutaneous

Question 28

# Measles virus member of_____virus in family paramyxoviridae worldwide, epidemics were common before_____ one of most_____of all viruses

Answer 28

morbilivirus vaccination infectious

Question 29

# Measles virus:clinical features Transmission:direct____contact incubation:2____ rash evolves from face to trunk to extremities fever and three Cs which are ? ____spots

Answer 29

droplet contact weeks cough,coryza and conjunctivitis koplik spots ## Footnote koplik spots:little sugary spots on mucosa next to molar teeth

Question 30

# Measles virus:clinical features complications are common in____and____ malnutrition esp____deficiency is a major cause of mortality

Answer 30

young kids and adults vitamin A