DNA viruses Adenoviruses, Parvoviruses, Papavoviruses, and Poxviruses

Question 1

Poxviruses:general concepts

Include human viruses_____&_______virus
some naturally infect animals and some can cause incidetal infection in______(zoonosis)

2 human specific viruses
variola(VARV)-______genus
molluscum contagiosum(MCV)____genus

Answer 1

smallpox(variola)&molluscım contagiosum virus
incidental infection in humans
Orthopox genus
molluscipox genus

Question 2

General concepts:poxviruses

formation of____,____nodules or disseminated____
____virus no longer exists but other poxviruses still can cause disease

Answer 2

lesions skin nodules disseminated rash
smallpox virus

Question 3

Smallpox(variola)

main transmission via____droplets
also capable of_____spread
virus survives for years in____
1st vaccine in 1796 later worldwide distribution led to____of smallpox by 1980

Answer 3

respiratory
capable of fomitic spread
scabs
eradictation

Question 4

smallpox(variola)

almost visible on_____microscopy
ovoid to____shaped complex morphology

largest viruses!!!

Answer 4

light
brick-shaped

Question 5

smallpox(variola)

viral genome consists of large____stranded linear___

Answer 5

double
DNA

Question 6

Smallpox(variola):replication

cycle takes place within the host cell_____
viral DNA replicates in ____-dense cytoplasmic inclusions

Answer 6

cytoplasm
electron-dense

electron-dense also known as Guarnieri’s inclusion bodies

Question 7

Smallpox(variola):pathogenesis

after inhaled, replicates in______tract
dissemination occurs via_____& cell-associated____Spread

Answer 7

upper respiratory tract
lymphatic viremic spread

Question 8

molluscum contagiosum and other poxviruses acquired through direct contact with____

Answer 8

lesions

Question 9

Smallpox(variola)clinical features

has___period 5-17 days
symptoms are____,_____ and___followed by___rash in mouth and on body
vomiting,diarrhea & excessive bleeding can be seen

Answer 9

high fever, rash, fatigue, severe headache and malaise
vesicular rash

Question 10

properities of natural smallpox that led to its eradication:viral char

exclusive_____host range no____reservoirs or vectors
single____
protected aganist all____

Answer 10

human host
animal reservoirs
serotype
infection

Question 11

Orf virus

human infection with orf or cowpox poxvirus of____&___
___infection
occupational hazard resulting from direct contact w/____on animal

Answer 11

goat & sheep
sore mouth infection
lesions on animal

Question 12

Orf virus:symptoms

single___ usually forms on point of contact
lesions may be mistaken for____

Answer 12

nodular lesion
anthrax

Question 13

Monkeypox-Mpox

symptoms start within____of exposure to virus
illness typically last___
tramission via contact w/___fluids,skin____ or____droplets,contaminated_____

Answer 13

3 weeks of exposure
2-4 weeks
body fluids, skin rash respiratory droplets contaminated fomites

Question 14

Mpox:pathogenesis

viral entry via____,____or____routes
Initial replication at____site followed by spread to local____
viremia phase when contacts w/____

Answer 14

oropharynx, nasopharynx or intradermal routes
inoculation site spread to local lymph nodes
blood

Question 15

Mpox:pathogenesis

contagious period:begins w/____viremia even before___appear
lesion development: starts in____then spreads to____
serum antibodies are detectable by the time___appear

Answer 15

secondary viremia
lesions
oropharynx spread to skin
lesions