RNA Viruses

Question 1

Genome characteristics

Answer 1

1. Single stranded + or - sense
2. Ds
3. Segmented

Question 2

RNA-dependent RNA polymerase

Answer 2

1. Encoded by viral genome
2. (-) ss, ds
3. Bring in own polymerase enzyme

Question 3

(-) sense ss RNA viruses

Answer 3

1. Paramyxoviruses
2. Orthomyxoviruses
   A. Influenza
3. Characteristics
   A. Enveloped
   B. Glycoproteins

Question 4

Paramyxoviruses

Answer 4

1. Diseases:
  A. Measles
  B. Mumps
  C. Resp: metapneumonovirus, parainfluenza virus
2. Enveloped
3. Glycoproteins -> syncytia formation
4. (-) sense ss RNA

Question 5

Orthomyxoviruses

Answer 5

1. Influenza
2. Enveloped
3. Segmented (-) sense ss RNA
4. Antigenic variation of glycoproteins
   A. Hemagglutin - attachment
   B. Neuraminidase - egression
5. Steal caps from host RNA

Question 6

(+) sense ssRNA viruses

Answer 6

1. Picornaviruses
   A. Enteroviruses
   B. Rhinoviruses
2. Retroviruses

H. Hepatitis

Question 7

Picornaviruses

Answer 7

1. Enteroviruses
  A. Small intestine
2. Rhinoviruses
  B. Nasal mucosa
3. Characteristics
  A. Naked, resistant to envir inactivation
  B. (+) sense ssRNA
4. Diseases
  A. Aseptic meningitis 
  B. Conjunctivitis
  C. Hand foot and mouth
  D. Herpangia
  E. Myostitis and myocarditis
  F. Common cold
  G. Encephalitis
  H. Hepatitis

Question 8

Retroviruses

Answer 8

1. HIV
2. 2 copies (+) sense ssRNA in capsid
3. (+)RNA -> dsDNA-> integrated
4. Reverse transcriptionase
5. Repeats on genome
6. Enveloped

Question 9

DsRNA viruses

Answer 9

1. Reovirus
  A. Rotavirus 
2. Characteristics:
  A. Segmented (8-11)
  B. Naked
  C. Capsid 3 layers -> resistant to envir inactivation
  D. DsRNA -> (-) RNA -> (+) RNA
  E. Brings RNA polymerase
3. Infantile diarrhea