Fungi

Question 1

True pathogens

Answer 1

1. Asperillus
2. Candida
3. Histoplasma

Question 2

Opportunistic infections

Answer 2

1. Cryptococcus

2. Pneumocystis

Question 3

Fungal diseases

Answer 3

1. Mycotic infections
2. Mycotoxicoses
3. Allergies to spores

Question 4

Mycotic infections

Answer 4

1. Candida albicans

2. Infect and replicate in tissues

Question 5

Mycotoxicoses

Answer 5

1. Amamitin and phalloidin (mushrooms)
2. Aflatoxin (peanuts)
3. Ergotism (grains_

Question 6

Fungal characteristics

Answer 6

1. Eukaryotic
2. Cell wall
   A. Chitin
   B. Ergosterol
   C. Antifungal target

Question 7

Fungal pathogenesis

Answer 7

1. Granuloma formation
  A. Coccidioidomycosis
  B. Histoplasmosis
  C. Blastomycosis
2. Acute suppuration = pustule
  A. Aspergillosis
  B. Sporotrichosis

Question 8

Dx of fungal infections

Answer 8

1. Direct microscopic exam
  A. Skin scraping, sputum sample
2. Culture of organism -Sabouraud’s agar
3. DNA probe tests
  A. PCR
4. Serologic tests

Question 9

Tx of fungal infections

Answer 9

1. Bind ergosterol
  A. Polyenes: nystatin, amphotericin B
2. Inhibit ergosterol synthesis
  A. Azoles: miconazole
  B. Allylamines: terbinafine
3. Inhibit nucleic acid synthesis
  A. Pyrimidines: flucytosine