Risk of ... inheritance Flashcards

1
Q

What are some factors which are important in determining weather offspring will survive?

A
  • Deleterious alleles

- Level of care

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2
Q

What is population genetics?

A

Change in alleles as a result of a change in selection pressures

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3
Q

What equations can be used to estimate the frequency of an allele in a population?

A

p +q =1

p^2 + 2pq + q^2 = 1

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4
Q

What are the conditions for the hardy-Weinberg equation to be true?

A
No mutations 
No migration 
No selection pressure 
Random mating 
large population 
Equal allele frequency in both sex
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5
Q

What does hardy-weinberg equation predict?

A

That the allele frequency will remain constant over time as long as the conditions are met.

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6
Q

What is assortative mating ?

A

Choosing a partner based on shared characteristics

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7
Q

What is consanguinity ?

A

Marriage between close blood relatives

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8
Q

What are two examples of non random mating?

A

Assortative and consanguinity

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9
Q

What is natural selection?

A

The gradual process by which biological traits become either more or less common in a population

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10
Q

What is positive selection?

A

Increase’s reproductive fitness and prevalence of adaptive traits giving a heterozygote advantage.

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11
Q

What is negative selection?

A

Reduction of reproductive fitness, decreases the prevalence of traits and gradual reduction of mutant alleles

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12
Q

Why is a large population important?

A

Because it can balance out fluctuations.

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13
Q

What are examples of times where change in population size has affected the allele frequency?

A

Statistical drift
Founder effect
Genetic drift
Bottleneck effect

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14
Q

What is genetic drift?

A

The random fluctuations in a trait from one generation to the next

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15
Q

What is statistical drift?

A

Is due to changes or random events.

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16
Q

What is the founder effect?

A

Change in trait frequency due to a small subset of the lager population stopping mating with the rest of the population

17
Q

What is the bottleneck effect ?

A

Population size becomes drastically reduced for one or more generations

18
Q

What does the body use as defence against cancer?

A

Oncogenes
Tumour suppressor genes
DNA damage-response genes

19
Q

What is a pro-oncogene

A

A normal gene that codes for proteins to regulate cell growth and differentiation.

20
Q

What is an oncogene?

A

A mutated proto-oncogene that can accelerate cell division

21
Q

What is a tumour suppressor gene

A

Cells growth breaks. Mutations cause increase allow cell cycle rate to increase and apoptosis to decrease

22
Q

What is a DNA damage-response gene?

A

Repair mechanisms for DNA

23
Q

What happens if DNA damage-response genes fail?

A

Cause HNPCC and MSI

24
Q

What is MMR

A

It corrects errors which occur. If it fails it causes MSI.

25
Q

What are the three types of tumour?

A

Benign
Dysplastic
Malignant

26
Q

What are the two ways in which genes can cause cancer?

A

Autosomal recessive syndromes - Both copies of the gene have an inherited mutation
De Novo mutations - Mutation in the germ cell of a parent

27
Q

What genes can breast and ovarian cancer be linked to?

A

BRCA1 and BRCA2

28
Q

Is Retinoblastoma heritable?

A

It can be, it also sometimes isent

29
Q

What genes increase the risk of colon cancer ?

A

MLh1 and MSH2 and MSH6 etc HNPACC