Rickets

Question 1

Where does rickets occur?

Answer 1

At the physeal zone of provisional calcification; leads to increased physeal width and cortical thinning and bowing

Question 2

What lab studies differentiate the various forms of rickets?

Answer 2

Ca, Phos, Alk Phos, PTH, Vit D, dihydroxy Vit D
Decreased Vit D- Vit D deficiency
Increased Alk Phos- hypophosphotasia
Decreased Ca, increased Phos- renal osteodystrophy
Increased Ca, decreased Phos- hyperparathyroidism
Normal Ca, decreased Phos- X linked

Question 3

What is rickets?

Answer 3

defect in mineralization of osteoid matrix caused by inadequate calcium and phosphate; called osteomalacia in adults

Question 4

Which of the following laboratory values would be consistent with nutritional rickets?

Answer 4

Increased PTH

Question 5

Loss of function in the 25(OH) vitamin D1-alpha hydroxylase gene causes which of the following diseases?

Answer 5

Hereditary Type II Vit D deficiency rickets

Question 6

Laboratory values of a normal serum calcium and parathyroid hormone can be found in which of the following disease states?

Answer 6

X-linked rickets; will have low Phos