PE/DVT

Question 1

What are the components of Virchow’s Triad?

Answer 1

1) venous stasis
2) hypercoagulable state
3) intimal injury

Question 2

What disorder has deficient inactivation of Factor V leading to a hypercoaguable state?

Answer 2

Factor V Leiden
Factor V functions as a cofactor to allow factor Xa to activate thrombin. Thrombin in turn cleaves fibrinogen to form fibrin, which polymerizes to form a clot. Deficiency prevents efficient inactivation of factor V by activated protein C causing overproduction of thrombin.

Question 3

What substance is released during dissection that leads to production of fibrin?

Answer 3

Thromboplastin

Question 4

What are signs and symptoms of PE?

Answer 4

1) acute onset pleuritic pain and dyspnea
2) tachypnea
3) tachycardia

Question 5

What are EKG findings in a PE?

Answer 5

S-wave in lead I
Q-wave in lead III
T-wave inversion in lead III