Anticoagulants

Question 1

What is the MOA of aspirin?

Answer 1

Inhibits the production of prostaglandins and thromboxanes

Question 2

What is the MOA of xarelto?

Answer 2

Direct Xa inhibitor

Question 3

What is the MOA of lovenox?

Answer 3

Enhancing ability of ATIII to inhibit factors IIa (thrombin) and Xa

Question 4

Protamine functions to reverse the pharmacologic effects of which of the following anti-coagulants?

Answer 4

Lovenox (enoxaparin)

Question 5

Low-molecular-weight heparin has been shown to have an increased rate of which of the following when compared to aspirin, clopidogrel, and compression devices?

Answer 5

Postoperative hematoma

Question 6

What is the MOA of warfarin?

Answer 6

inhibits vitamin K 2,3-epoxide reductase; prevents reduction of vitamin K epoxide back to active vitamin K
vitamin K is needed for gamma-carboxylation of glutamic acid for factors: II (prothrombin), VII (first affected), IX, X
protein C, protein S

Question 7

What herbal substances can increase the risk of bleeding?

Answer 7

gingko, ginsing, and garlic

Ginko and ginsing affect platelets

Question 8

What is the MOA of transexamic acid?

Answer 8

competitively inhibits the activation of plasminogen by binding to the lysine binding site
Dosing: 10-20 mg/kg initial bolus dose followed by repeated doses of the initial TXA dose every 3 hours for 1-4 doses
10-20mg initial bolus followed either by an infusion of 1-10 mg/kg/hr for 4-30 hours