Rheumatology Flashcards

1
Q

Heberden v. Bouchard Nodes

A

Heberden = DIP joint (DISTAL) - “heberden at the end”

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2
Q

Gout Tx

A

Acute - NSAIDs or steroids (if NSAIDs not working or renal insufficiency)

Chronic - allopurinol / febuoxstat if production problem
OR probenecid if excretion problem

Colchicine helps prevent subsequent attacks

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3
Q

What anti-hypertensive can contribute to gout? What should patient’s be switched to?

A

HCTZ

Switch to losartan (lowers uric acid)

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4
Q

What conditions are associated w/ pseudo gout?

A

Hemochromatosis & hyperparathyroidism

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5
Q

When should you image someone with lower back pain/

A

Hx cancer

Focal neuro deficits

Point tenderness along spine, fever, high ESR w/ sensory level (suggests possible epidural abscess)

Cauda equina - bowel/bladder problems, saddle anesthesia

NOT FOR SCIATICA ALONE (+ straight leg raise)

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6
Q

What is the first step in someone with signs of SC compression?

A

STEROIDS (dexamethasone) b/f imaging

Even if 2/2 tumor or epidural abscess

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7
Q

Tx of Dupuytren Contracture

A

Early - collagenase injection

Later - triamcinolone or lidocaine injections

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8
Q

Planter Fasciitis

A

Severe pain at bottom of foot near fascia insertion at calcaneus

Worst in morning, improves w/ few steps

Tx = stretch, arch supports, NSAIDs, later steroid injection if needed

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9
Q

Felty Syndrome

A

RA

Splenomegaly

Neutropenia

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10
Q

Caplan Syndrome

A

RA

Pneumoconiosis

Lung nodules

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11
Q

What is the most common cause of death in RA?

A

CAD

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12
Q

RA Treatment (common side effects / considerations)

A

1 = Methotrexate (liver, lungs, BM suppression)

Acute - NSAIDs and steroids

DMARDs - hydroxychloroquine if mild (retinal exam)

THEN anti-TNF (check Tb) or rituximab (risk infections)

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13
Q

Presentation of Juvenile Rheumatoid Arthritis

A

High fever w/o known origin + rash

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14
Q

STILLS

A

Salmon-colored rash

High temp

Lymphadenopathy and leukocytosis

Splenomegaly

Inc Ferritin (acute phase reactant)

Tx - ASA or NSAIDs –> steroids if no response

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15
Q

Which markers correlate w/ disease activity in SLE?

A

Dec in complement

Inc in anti-DS DNA

NOT ANA

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16
Q

What do you do if you find + anti-SSA or anti-Ro in pregnant woman?

A

Means high risk passing SLE to baby

Check baby EKG b/c at risk for heart block

17
Q

Labs in Anti-phospholipid Syndrome

A

Elevated aPTT (normal PT / INR)

False pos VLDR or RPR

No correction w/ mixing study

Prolonged RVVT

18
Q

When should you test for anti-cardiolipin in relation to abortions?

A

If 2 1st trimester losses OR 1 2nd trimester loss

19
Q

How do you treat moms w/ anti-cardiolipin to prevent abortion?

A

Heparin + ASA (no warfarin in pregnancy)

20
Q

Scleroderma Renal Crisis

A

Sudden hypertensive crisis

Treat w/ ACE (even if high Cr)

21
Q

Inclusion Body Myositis

A

Weakness of proximal AND DISTAL muscles (esp upper extremity flexors)

Diagnose w/ muscle biopsy

No Tx

22
Q

What is the specific antibody associated w/ mixed connective tissue disease?

A

anti-U1-RNP

23
Q

What is the most dangerous complication of Sjogrens?

A

lymphoma

24
Q

What is PAN associated with?

A

Hep B and C - test and treat

NO LUNGS INVOLVED

25
Q

What is the best test to diagnose GPA/Wegener’s?

How does it often present?

A

Lung biopsy&raquo_space; kidney or sinus biopsy

Presents as pneumonia not responding to abx

26
Q

Which specific complement protein is associated w/ SLE? Hep C?

A

SLE = C3

Hep C = C4

27
Q

Ankylosing Spondylitis

A

Young men

Lower back pain & stiffness; better w/ use (like RA)

Dec chest expansion and fusion of lumbar spine

Enthesopathy of achilles tendon (inflammation at attachment point)

Uveitis

Arthritis (transient)

AV block or aortic insufficiency

Dx - xray sacroiliac joint first; then MRI, ESR

Tx - exercise and NSAIDs; later anti-TNF, NO STEROIDS

28
Q

Classic Triad of Reiter + 3 Things it’s 2/2

A

1 - joint pain
2 - ocular findings (uveitis)
3 - GU problems (urethritis)
“can’t see, can’t pee, can’t bend my knee”

Associated w/ … IBD, STDs, GI infection like Yersinia, Campylobacter, salmonella

29
Q

Joint Fluid WBC Count in Septic Arthritis

A

> 50,000 (neutrophils)

30
Q

How do you treat infected prosthetic joint?

A

Remove joint –> treat w/ abx for 6-8 wks –> replace joint

31
Q

Gonococcal Arthritis (how does it present and what should you do?)

A

1 - STD in hx
2 - polyarticular sepsis
3 - Tenosynovitis
4 - rash - petechial

Swab rectum, pharynx, urethra and cervix for culture

Tx = ceftriaxone, cefotaxime

If recurrent … test for terminal complement deficiency