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Pediatrics > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

2 events considered necessary for the juvenile RA to occur

A

Immunogenetic susceptibility and external environmental trigger

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2
Q

HLA of patients with juvenile RA Polyarticular disease

A

HLA DR4

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3
Q

2 HLA of patients with juvenile RA pauciarticular disease

A

HLA DR8 and DR5

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4
Q

Difference between pauciarticular and polyarticular types of juvenile RA in terms of number of joints involved

A

Poly - 5 or more

Pauci -

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5
Q

Morning stiffness, ease of fatigue especially after school in the early afternoon, joint pain later in the day, and joint swelling

A

Juvenile RA

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6
Q

Type of juvenile RA that is associated with chronic uveitis

A

Pauciarticular

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7
Q

(+) RF in juvenile RA portends a poor or good prognosis

A

Poor

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8
Q

(+) ANA in juvenile RA portends a poor or good prognosis

A

Good

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9
Q

Most common pediatric rheumatic disease witg arthritis as the distinguishing manifestation

A

Juvenile idiopathic arthritis or juvenile RA

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10
Q

Systemic juvenile RA has what pattern of fever?

A

Quotidian pattern (1-3 spikes in 24 hours with rapid return to baseline or subnormal levels)

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11
Q

Duration of juvenile RA

A

6 weeks or more

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12
Q

Treatment of juvenile RA

A

NSAIDS (first line)
Methotrexate
Steroids

Physical and occupational therapy
Surgery

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13
Q

Rheumatoid disorder characterized by absence of RF, ANA, and other markers

A

Juvenile spondyloarthropathy

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14
Q

Triad of arthritis, conjunctivitis, and urethritis caused by Chlamydia trachomatis

A

Reiter’s disease

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15
Q

HLA for ankylosing spondylitis

A

B27

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16
Q

Characterized by presence of enthesitis

A

Ankylosing spondylitis

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17
Q

Inflammation at the sites of attachments of ligaments, tendons, fascia, and capsule to bone

A

Enthesitis

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18
Q

X-ray finding in ankylosing spondylitis

A

Sacroilitis

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19
Q

Serologic markers specific for SLE

A

Anti-dsDNA AND anti-Sm

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20
Q

Serologic markers for SLE that may be used as marker for active disease especially lupus nephritis

A

Anti-dsDNA

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21
Q

Mainstay of therapy for SLE

A

Glucocorticoids

22
Q

Drug useful for children with severe lupus nephritis and CNS lupus

A

Cyclophosphamide

Other: azathioprine, methotrexate, cyclosporine

23
Q

5-yr survival rate of SLE

A

90%

24
Q

Heliotrope discoloration of the eyelids with periorbital edema and erythematous papules over the extensor surfaces of the joints, and Gottron papules in the ankle

A

Dermatomyositis

25
Q

Most common of the pediatric inflammatory myopathies

A

Dermatomyositis

26
Q

Etiology of dermatomyositis

A

Coxsackie B and GABHS

Exposure to sun is a cofactor

27
Q

HLA in dermatomyositis

A

Ag DQA1*0501

28
Q

Excessive accumulation of collagen in the skin and other organs

A

Scleroderma

29
Q

Skin thickening with loss of dermal ridges, resembling tightened skin

A

Scleroderma

30
Q

Antibodies in limited scleroderma

A

Anti centromere

31
Q

Antibodies for systemic scleroderma

A

Anti Scl 70

32
Q

Earliest manifestation of scleroderma

A

Reynauds phenomenon

33
Q

Scleroderma associated with CREST

A

Limited scleroderma

34
Q

HSP is mediated by

A

IgA

35
Q

Involved vessels in HSP

A

Small blood vessels

36
Q

Skin biopsy result of leukocytoclastic angiitis; renal biopsy result of IgA mesangial deposition

A

HSP

37
Q

Treatment of HSP

A

Symptomatic
Self limiting

Steroids for severe abdominal pain

38
Q

Monitoring for HSP patients

A

Urinalysis every 3 months for 1 years (high recurrence rate)

39
Q

Polyarteritis nodosa is associated with what infection in adults? In children?

A

Hep B; GABHS

40
Q

Medium vessel or small vessel vasculitis characterized by aneurysms and thrombosis (brachial, femoral, or mesenteric arteries)

A

Polyarteritis nodosa

Immune complex disease

41
Q

Livedo reticularis, subcutaneous nodules with skin, GI, and kidney involvement

A

Polyarteritis nodosa

With HPN, peripheral neuropathy

42
Q

Treatment of polyarteritis nodosa

A

High dose corticosteroid

Cyclophosphamide

43
Q

Characterized by necrotizing granulomas in multiple organs, most commonly the respiratory tract and kidneys

A

Wegener’s granulomatosis

44
Q

Severe sinusitis, hemoptysis and glomerulonephritis are seen in

A

Wegener’s granulomatosis

45
Q

Antibodies in wegener’s granulomatosis

A

c-ANCA

46
Q

A vasculitis syndrome characterized by a triad of aphthous stomatitis, genital ulceration, and uveitis

A

Behcet’s disease

CNS and GI involvement

47
Q

Treatment of Behcet’s disease

A

Corticosteroids and thalidomide

48
Q

Skin reaction to a needleprick seen in Behcet’s disease

A

Pathergy

49
Q

What is the most serious cardiac complication of neonatal lupus?

A

Heart block

50
Q

Puffiness around fingers, dorsum of the hands and face, followed by skin tightening

A

Systemic sclerosis

51
Q

Sclerodactyly, digital pitting scars, and bibasal pulmonary fibrosis are minor criteria for

A

Systemic sclerosis

Major criteria: proximal scleroderma

52
Q

Medications that may prevent fingertip ulcerations

A

Calcium channel blockers and ACE inhibitors

Pediatrics (8 decks)

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