Rheumatology Flashcards
Vasculitis that affects visceral arteries and can present with abdominal pain
Polyarteritis nodosa
What is a vasculitis that attacks the coronary arteries in young children
Kawasaki disease
Vasculitis that presents as recurrent asthma attacks
Chung-Strauss
Vasculitis that presents as recurrent sinusitis, dyspnea’ and/or hemoptysis
Wegener granulomatosis
Vasculitis that presents with new onset HA, scalp tenderness, and jaw claudication
Temporal arteritis
Vasculitis that affects large vessels and may cause syncope
Takayasu Arteritis
PE signs with vasculitis
Palpable purpura that don’t blanch
Red to purple in color
Other causes of palpable purpura
Disseminated meningococcal or gonococcal
Rocky Mountain spotted fever
Hallmark lab finding of churg Strauss
Eosinophilia
C-ANCA positive is diagnostic for what
Wegners granulomatosis
P-ANCA positive is seen in what vasculitis
Microscopic polyangitis
Churg-Strauss
Definitive test to document inflammation and destruction of vessels
Biopsy
Mainstay of tx for wegners granulomatosis, microscopic polyangitis, polyarteritis nodosa
Prednisone and cyclophosphamide
Tx for temporal arteritis and churg Strauss
Prednisone
Peak age of RA
40-50
Gender more at risk for RA
Female
What causes RA
Synovial T cells become activated and synovial lining becomes invasive causing erosion and destruction of joint cartilage
High levels of what factors in RA synovial fluid
Tumor necrosis factor alpha
Interleukin-1
Key feature with RA
Morning stiffness >1 hour
RA deformity at the PIP
Boutonnière deformity
RA deformity at the DIP
Swan neck deformity
Most commonly affected joints with RA
Proximal inter phalangeal
mCP
Wrist
What is the syndrome with splenomegaly, RA, leukopenia
felty syndrome
Presents with GU or GI dz and asymmetric lower extremity arthritis
Reactive arthritis
Presents with monoarticular knee arthritis with preceding rash and fever
Lyme disease
Lab tests for RA
RF
Anti-CCP
Plain films of hands
What is used as a bridge for RA when waiting for DMARDs to kick in
Corticosteroids
Most common DMARD and adrs
Methotrexate- bone marrow toxicity, hepatic fibrosis, pneumonitis’ stomatitis
Pyrmidine synthesis inhibitior used for RA. Adrs include diarrhea and rash
Leflunomide
Extra-articular manifestations of RA
Rheumatoid nodules
Pleural effusions
Vasculitis
Felty syndrome
Associated conditions with RA
Atlantoaxial subluxation
Baker cyst
