Rheumatology Flashcards
cervical spondylosis
What are the clinical findings of ankylosing spondylitis?
reduced chest expansion, reduced lateral flexion and reduced forward flexion (Schober’s test)
Sulfasalazine can cause what?
Reduced sperm count -> usually returns to normal upon stopping the medication
What would joint aspiration of rheumatoid arthritis show?
- High WBC
- Polymorph neutrophils
- Cloudy/Yellow appearance
What is previous chemo a big risk factor for?
Avascular necrosis
Methotrexate plus trimethoprim can cause what?
Bone marrow suppression and panycytopenia
DIP swelling and dactylitis with arthritis suggests what?
Psoriatic arthritis
Which antibody is specific for anti-phospholipid syndrome?
Anticardiolipin antibody
What are the smoking cessation drugs?
- Nicotine replacement (causes N+V, headaches, flu symptoms)
- Varenicline (causes nausea and C/I in pregnancy/BF)
- Bupropion (reduces seizure threshold)
What type of shock does tension pneumothorax cause?
Obstructive
Which lung cancer is gynaecomastia associated with?
Adenocarcinoma of the lung
What does an isolated rise in ALP suggest?
Pagets disease of the bones
What is Paget’s disease of the bone?
Increased but uncontrolled bone turnover- XS osteoclast resorption and increased osteoblastic activity
What is most commonly affected in Paget’s
Skull, spine/pelvis, long bones of lower extremities
Paget’s predisposing factors?
Age, male, northern latitude, FHx
Paget’s CP
- 5% symptomatic
- older male with bone pain and raised ALP
- bone pain: pelvis, lumbar, femur
- bowing of tibia, bossing of skull
Paget’s Ix
- bloods
- other markers of bone turnover
- x-ray= osteolysis in early disease; mixed lytic/sclerotic lesions later. Skull= thickened vault, osteoporosis circumscripta
- Bone scintigraphy (increased uptake at sites of active bone lesions)
Bloods in Paget’s?
- Raised ALP
- Ca and phosphate normal (sometimes hypercalcaemia with prolonged immobilisation)
Other markers of bone turnover in Paget’s?
- procollagen type I N-terminal propeptide (PINP)
- serum C-telopeptide (CTx)
- urinary N-telopeptide (NTx)
- urinary hydroxyproline
Paget’s Mx?
- Bisphosphonate (oral risedronate or IV zoledronate)
- calcitonin less common
Paget’s indications for Mx
Bone pain, skull or long bone deformity, fracture, periarticular Paget’s
Paget’s Cx
Deafness, bone sarcoma, fractures, skull thickening, high-output cardiac failure
subchondral erosions, sclerosis
and squaring of lumbar vertebrae
Anklyosing spondylitis
What is the most common site of metatarsal stress fractures?
2nd metatarsal
hyperpigmentation of the palmar creases indicates what?
Addisons
How should proximal scaphoid pole fracture be managed?
Refer to orthopaedics for surgical fixation
Features of a acetabular labral tear?
- Following trauma
- Hip/groin pain
- Snapping sensation
Features of a femoroacetabular impingement?
- More chronic history
Long term steroid use/chemo therapy + someone with hip pain suggests?
Avascular necrosis of the hip
Pain following tibial surgery?
Compartment syndrome
What is the management of AVN?
If displaced: total hip replacement for anyone who is mobile, no co-morbidities etc otherwise hemiarthroplasty
If not displaced: internal fixation
Rheumatic vs psoriatic arthritis?
Psoriatic will be asymmetrical
When should uric acid levels be measured again with gout?
2 weeks after the flare has settled
X-ray findings for rheumatoid arthritis
L – loss of joint space
E – erosions
S – soft tissue swelling
S – soft bones (periarticular osteopenia)
+ juxta-articular osteoporosis
subluxation
Extra-articular manifestations of RA?
Nodules, scleritis, episcleritis, pleural effusion, Felty, anaemia, Raynaud’s, carpal tunnel
RA, Splenomegaly and neutropenia?
Felty
Antibody of choice for RA
Anti-ccp
Hand signs for RA
- Ulnar deviation
- Swan neck deformity
- Z neck thumb
- Muscle wasting
- Wrist subluxation
What organism can cause septic arthritis with metal joint?
Early stages after surgery - staph aureus
Later onset - staph epidermidis
What are risk factors for septic arthritis?
RA, DM, Immunosuppression, Penetrating injury, infection elsewhere
What are the rotator cuff muscles?
Supraspinatus
Infraspinatus
Teres minor
Subscapularis
What muscles are responsible for shoulder abduction?
0-15 degrees: supraspinatus
15 - 90 degrees: deltoid
90 degrees+: Trapezius and serratus anterior
Which muscles does the accessory nerve innervate?
Deltoid and teres minor
Investigations to assess for supraspinatus impingement?
US and MRI
Proximal muscle weakness + raised CK + no rash
Polymyositis
Dermatomyositis vs polymyositis
Dermatomyositis would have a rash
What would be seen on X-ray to support a diagnosis of ankylosing spondylitis?
Sacro-ilitis
What should be given to women >75 with a fragility fracture?
Bisphosphonates
When should a referral for sciatica be considered?
4-6 weeks after analgesia + physio treatment
What are the features of ankylosing spondylitis?
Apical fibrosis
Anterior uveitis
Aortic regurgitation
Achilles tendonitis
AV node block
Amyloidosis
and cauda equina syndrome
Pain worse on walking on tip toes?
Plantar fasciitis
Fever + back pain + IVDU
Iliopsoas abscess
What is the treatment for psoas abscess?
Abx + percutaneous drainage
muscle wasting of the hands, numbness and tingling and possibly autonomic symptoms
Neurogenic thoracic outlet syndrome
What is osteomalacia?
Softening of the bones secondary to vit D deficiency
How does osteomalacia present?
- Bone pain/tenderness
- Fractures e.g NOF
- Proximal myopathy: waddling gait
How would osteomalavcia present on investigations?
- Low Vit D
- Low calcium and phosphate
- Raised ALP
- Translucent bands over the X-ray
Management of NOF fractures
Non-displaced + intracapsular: cannulated screw fixation
Stable + extra capsular: dynamic hip screw
Displaced + Intacapsular if not very mobile older patient: Hemiarthroplaty
Displaced + intracapsular if young/mobile older patient: Total hip arthroplasty
flexion deformities of his 4th and 5th digit which cannot be passively corrected
Duputrynes contracture
What is often the earliest sign of Dupuytrens?
Firm, thickened palmar nodule over the metacarpal head
What are risk factors for Dupuytrens?
- Diabetes
- Alcohol
- FH
- AIDS
Limited vs diffuse cutaneous systemic sclerosis
Diffuse will have widespread skin and organ involvement (lungs and kidneys)
What is fat embolism?
A syndrome secondary to trauma/fractures/orthopaedic surgery
How does fat embolism present?
Pulmonary: PE like symptoms
Neuro: altered mental status, seizures, coma
Derm: petechial rash on upper body
Managed with supportive treatment/prophylaxis
What are common precipitants of gout?
- Surgery
- Dehydration
- Alcohol
- Trauma
- Infection
- Foods rich in purines
What are x-ray findings of gout?
- Normal joint space
- Soft tissue swelling
- Periarticular erosions
What can be some examination findings of osteoarthritis?
- Antalgic gait
- Joint swelling
- Joint tenderness
- Pain on movement
- Crepitus
- Reduced ROM
purple discolouration of eyelids in dermatomyositis?
Heliotrope
What are Gottron’s papules?
Rough, red papules over the knuckles -> dermatomyositis
What antibodies are associated with dermatomyositis?
Anti-Jo, Anti-MI, RF, ANA
What is Raynauds phenomenon?
Peripheral digital ischaemic caused by vasospasm which is precipitated by cold/emotion
What are some causes of Raynauds phenomenon?
- SLE
- Raynaud’s disease
- RA
- Ehler-Danlos
- Beta blockers
- Atherosclerosis
What are the features of CREST?
Calcinosis
Raynaud’s
Oesophageal dysmotility
Sclerodactyly
Telangiectasia
What respiratory condition is associated with AS?
Pulmonary fibrosis
What is mononeuritis multiplex?
Damage to 2+ peripheral nerves
What are causes of mononeuritis multiplex?
- HIV/AIDS
- Diabetes
- RA
- Sarcoidosis
What is the definitive investigation for Sjogrens?
Salivary gland biopsy
What is the most common cause of cauda equina syndrome?
Lumbar disc herniation at L4/L5/ or L5/S1
Pseudogout is strongly associated with what?
Haemochromatosis
What are the most specific markers for SLE?
anti-dsDNA and anti-SM
ANA - most sensitive
Erb’s palsy has injury to which myotomes?
C5 and C6 (11 erbs and spices)
How does Erb’s palsy present?
Imparied wrist extension and elbow flexion - waiters tip
Carbamazepine increases risk of what?
Osteoporosis
Back pain red flags?
- Thoracic or cervical spine pain
- Progressive pain not relieved by rest
- Fevers, chills, weight loss
- Early morning stiffness > 30 mins
- Bowel/bladder/neuro dysfunction
What should be given for cord compression secondary to bone metastases?
Dexamethasone
Osteoporosis risk factors?
Steroids
Hyperthyroidism/Hyperparathyroidism
Alcohol/Smoking
Thin
Testosterone deficiency
Early menopause
Renal failure
Erosive bone disease
Diabetes
What is a Colles fracture?
Fracture of the distal radium with dorsal angulation of the distal fracture fragments
Septic Arthritis in a prosthetic joint?
Admit patient and arrange ortho review
pain and swelling at the base of the thumb and along the radial aspect of the wrist, often worsened by thumb movement or grasping in a YOUNG person
De Quervain;s tenosynovitis
What should take place before starting anyone on biologics?
Quantiferon test - assess for TB as biologics can reactivate latent TB
Abx regiment for septic arthritis?
2 weeks of IV plus 4 weeks of orals
Which antibodies are specific for anti phospholipid
Anti-beta-2-glycoprotein I antibody
What is a common early finding in professional players who have had trauma?
Osteoarthritis
What cover should be given to those receiving allopurinol?
NSAIDs cover for 3 months as allopurinol can acutely raise urate levels