Rheumatology Flashcards
Which symptom is NOT typical to lower leg nerve root compression?
A) Positive Lasegue-sign
B) Tenderness at the Valleix points
C) Positive femoral sign
D) Loss of the Achilles tendon reflex
E) Patellar ballottement
E) Patellar ballottement
What medicine is NOT used to treat rheumatoid arthritis?
A) Methotrexate
B) Leflunomide
C) Methylprednisolone
D) Diclofenac
E) Colchicine
E) Colchicine
Which of the following is an interleukin-6 R-inhibitor biological drug?
A) Etanercept
B) Adalimumab
C) Tocilizumab
D) Infliximab
E) Rituximab
C) Tocilizumab
Which clinical symptom is NOT characteristic of rheumatoid arthritis?
A) Early morning stiffness in the hands
B) Symmetrical small joint inflammation of the hands
C) Small joint erosions on X-ray
D) Anti-CCP positivity
E) Early low back pain with sacroiliitis
E) Early low back pain with sacroiliitis
Which symptom is NOT characteristic of Felty syndrome?
A) Inflammatory arthritis
B) High titer rheumatoid factor positivity
C) Splenomegaly
D) Pneumoconiosis
E) Granulocytopenia
D) Pneumoconiosis
It does NOT belong to the characteristics of adult-onset Still’s disease
A) Pigmented villonodular synovitis
B) High fever
C) Maculopapular rash on the upper arms
D) Arthralgia
E) Visceral symptoms
A) Pigmented villonodular synovitis
It does NOT belong to the diagnostic criteria for systemic lupus erythematosus:
A) Anti-DNA positivity
B) Nervous system manifestation
C) Erosive arthritis
D) Renal involvement
E) Butterfly (malar) rash
C) Erosive arthritis
Which is the most common autoimmune disease among the following?
A) Systemic lupus erythematosus
B) Rheumatoid arthritis
C) Systemic sclerosis
D) Sjögren syndrome
E) Dermatomyositis
B) Rheumatoid arthritis
Which advanced disease state could be characterized by subcutaneous rheumatoid nodules?
A) Polymyalgia rheumatica
B) Systemic lupus erythematosus
C) Rheumatoid arthritis
D) Ankylosing spondylitis
E) Systemic sclerosis
C) Rheumatoid arthritis
Which of the listed diseases is more common in men?
A) Ankylosing spondylitis
B) Rheumatoid arthritis
C) Systemic lupus erythematosus
D) Polymyalgia rheumatica
E) Sjögren syndrome
A) Ankylosing spondylitis
What is the base (first-line) therapy for rheumatoid arthritis?
A) Sulfasalazine
B) Cyclophosphamide
C) Methotrexate
D) Chloroquine
E) Azathioprine
C) Methotrexate
What is the most important immunological marker of mixed connective tissue disease (MCTD)?
A) Anti-CCP
B) Antinuclear factor
C) Anti-SSA
D) Anti-U1RNP
E) Anti-SSB
D) Anti-U1RNP
What joints are NOT affected in rheumatoid arthritis?
A) Metacarpophalangeal (MCP) joints
B) Proximal interphalangeal (PIP) joints
C) Distal interphalangeal (DIP) joints
D) Knee joints
E) Radiocarpal joints
C) Distal interphalangeal (DIP) joints
What side effect is NOT characteristic of the antirheumatic biological treatment?
A) Bone marrow depression
B) Elevated liver enzymes
C) Growing joint complaints
D) Allergic skin reaction
E) Latent tuberculosis flare-up
C) Growing joint complaints
Symptoms of sarcoidosis, EXCEPT:
A) Granulomatous systemic process
B) Bilateral hilaris lymphadenopathy
C) Erythema nodosum
D) Arthritis
E) Polychondritis
E) Polychondritis
What subgroup of juvenile idiopathic arthritis is characterized primarily by rheumatoid factor positivity?
A) Polyarthritis
B) Systemic form
C) Oligoarthritis
D) Enthesopathic arthritis
E) Psoriatic arthritis
A) Polyarthritis
NOT a symptom of Scheuermann’s disease:
A) Dorsal hyperkyphosis
B) Forwardly wedge-shaped vertebrae formation
C) Uneven vertebrae closing plates
D) Moderate back pain of teenagers
E) Association of avascular necrosis of femoral head
E) Association of avascular necrosis of femoral head
It does NOT belong to seronegative spondyloarthritis:
A) Ankylosing spondylitis
B) Reactive arthritis
C) Enteropathic arthritis
D) Polymyalgia rheumatica
E) Psoriatic arthritis
D) Polymyalgia rheumatica
NOT characteristic of ankylosing spondylitis:
A) Elevated erythrocyte sedimentation rate
B) Low back pain worsens after activity, improves after rest
C) Low back pain worsens during early morning rest, improves with activity
D) Early bilateral sacroiliitis
E) Syndesmophytes on spinal X-ray
B) Low back pain worsens after activity, improves after rest
Characteristics of joint processes associated with inflammatory bowel diseases (IBD), EXCEPT
A) Especially lower extremities oligoarthritis
B) Spondarthritis of the spine
C) Effectiveness of infliximab therapy
D) Effectiveness of sulfasalazine therapy
E) Effectiveness of methotrexate therapy
E) Effectiveness of methotrexate therapy
Which pathogen causes Lyme disease?
A) Campylobacter jejuni
B) Klebsiella pneumoniae
C) Borrelia burgdorferi
D) Coxsackie virus
E) Epstein-Barr virus
C) Borrelia burgdorferi
What symptom group is NOT characteristic of Lyme disease?
A) Erythema migrans
B) Arthralgia - Arthritis
C) Neurological lesions
D) Cardiac changes
E) Severe gastrointestinal symptoms
E) Severe gastrointestinal symptoms
Which medicine is NOT effective for treating an acute gout attack?
A) Allopurinol
B) Corticosteroid
C) Colchicine
D) Non-steroidal anti-inflammatory drugs
E) TNF-α inhibiting biological agents
A) Allopurinol
What is the absolute classification criteria for gout diagnosis?
A) Detection of synovial monosodium monohydrate crystals
B) Uric acid nephrolithiasis
C) Occurrence of acute flares of gouty arthritis
D) The presence of tophuses
E) Hyperuricemia
A) Detection of synovial monosodium monohydrate crystals
What is the most important laboratory symptom of primary osteoporosis?
A) Elevated alkaline phosphatase
B) Elevated erythrocyte sedimentation rate
C) Elevated parathyroid hormone levels
D) Decreased serum calcium levels
E) None of the above
E) None of the above
Which bone disease is NOT characterized by elevated serum alkaline phosphatase?
A) Osteoporosis
B) Osteomalacia
C) Primary hyperparathyroidism
D) Paget’s disease of the bones
E) Secondary hyperparathyroidism
A) Osteoporosis
What condition does NOT lead to increased formation of osteoarthritis?
A) Hip joint dysplasia
B) Significant weight gain
C) Varus / valgus deformity
D) Excessive arthritis
E) HLA B-27 positivity
E) HLA B-27 positivity
In which joints does Heberden’s osteoarthritis develop?
A) In distal interphalangeal joints
B) In proximal interphalangeal joints
C) In knee joints
D) In the small joints of the leg
E) Anywhere
A) In distal interphalangeal joints
Typical symptoms of lumbar discus herniation, EXCEPT
A) Antalgic posture
B) Strong lumbar back pain
C) Motor weakness of the lower extremities
D) Loss of tendon reflexes on the lower limbs
E) Acute abdominal complaints
E) Acute abdominal complaints
NOT a characteristic hand change of rheumatoid arthritis:
A) Erosions of the small joints
B) Subluxations of the small joints
C) “Pencil in cup” lesion
D) Bone ankylosis
E) Swan-neck and boutonniere finger deformity on the hands
C) “Pencil in cup” lesion
It does NOT play an important role in the pathogenesis of rheumatoid arthritis:
A) Activation of Th1 line
B) Activation of the Th17 line
C) Activation of the Th2 line
D) Decreased operation of Treg cells
E) Decreased formation of cathepsins
E) Decreased formation of cathepsins
Which illness is associated with increased erythrocyte sedimentation rate of the following?
1) Osteoporosis
2) Psoriatic arthritis
3) Osteoarthritis
4) Rheumatoid arthritis
5) Polymyalgia rheumatica
A) the 1st, 4th and 5th answers are correct
B) the 2nd, 4th and 5th answers are correct
C) the 1st, 3rd and 4th answers are correct
D) the 2nd, 3rd and 4th answers are correct
E) the 1st, 2nd and 5th answers are correct
B) the 2nd, 4th and 5th answers are correct
What are the contraindications of antirheumatic biological therapy?
1) Strong joint arthritis
2) Active tuberculosis
3) NYHA class 3-4 heart failure
4) The existence of malignant disease
5) Rheumatoid factor positivity
A) the 1st, 3rd and 4th answers are correct
B) the 2nd, 3rd and 5th answers are correct
C) the 2nd, 3rd and 4th answers are correct
D) the 3rd, 4th and 5th answers are correct
E) the 1st, 2nd and 3rd answers are correct
C) the 2nd, 3rd and 4th answers are correct
Genetic subtypes predominant to rheumatoid arthritis:
1) HLA DRB101
2) HLA DRB104
3) HLA DRB1*10
4) HLA B27
5) HLA B35
A) the 1st, 2nd and 4th answers are correct
B) the 1st, 3rd and 5th answers are correct
C) the 1st, 2nd and 3rd answers are correct
D) the 3rd, 4th and 5th answers are correct
E) the 2nd, 3rd and 5th answers are correct
C) the 1st, 2nd and 3rd answers are correct
Characteristics of juvenile idiopathic arthritis
1) Begins before the age of 16
2) Growth restriction of the child
3) Reduced mental development of the child
4) Joint pain is generally mild
5) Biological therapy not applicable
A) the 1st, 2.nd and 4th answers are correct
B) the 1st, 3rd and 4th answers are correct
C) the 1st, 4th and 5th answers are correct
D) the 1st, 2nd and 3rd answers are correct
E) the 1st, 3rd and 5th answers are correct
A) the 1st, 2.nd and 4th answers are correct
Clinical changes in ankylosing spondylitis:
1) Ankylosing inflammation of the spine
2) Association of acute anterior uveitis
3) More frequent association of lymphomas
4) Peripheral enthesitis
5) Sicca syndrome
A) the 1st, 2nd and 5th answers are correct
B) the 1st, 2nd and 4th answers are correct
C) the 1st, 2nd and 3rd answers are correct
D) the 1st, 3rd and 4th answers are correct
E) the 1st, 4th and 5th answers are correct
B) the 1st, 2nd and 4th answers are correct
Which drugs are used to treat osteoporosis from the following?
1) Bisphosphonates
2) Teriparatide
3) Hyaluronic acid
4) Denosumab against RANKL
5) Chondroitin sulphate
A) the 1st, 2nd and 4th answers are correct
B) the 1st, 3rd and 5th answers are correct
C) the 1st., 2nd and 5th answers are correct
D) the 1st, 3rd and 4th answers are correct
E) the 2nd, 4th and 5th answers are correct
A) the 1st, 2nd and 4th answers are correct
