Rheumatology Flashcards

1
Q

Give four extra-articular features of rheumatoid arthritis

A
  • Scleritis
  • Episcleritis
  • Carpal tunnel syndrome
  • Raynaud’s phenomenon
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2
Q

What is Felty’s syndrome?

A
  • Complication of RA

- Triad of RA, low WCC and splenomegaly

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3
Q

Give three triggers for an attack of gout

A
  • Trauma
  • Dehydration
  • Alcohol excess
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4
Q

Which investigation is diagnostic in gout/pseudogout?

A

Polarised light microscopy of synovial fluid

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5
Q

Which three joints are most commonly affected by pseudogout?

A
  • Knee (most common)
  • Hip
  • Wrist
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6
Q

Which other conditions are associated with pseudogout? Give three examples

A
  • Haemochromatosis
  • Hypothyroidism
  • Hyperparathyroidism
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7
Q

What are the textbook cutaneous features of SLE?

A
  • Malar rash
  • Discoid rash
  • Photosensitive rash
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8
Q

What are the features of anti-phospholipid syndrome?

How is this condition managed?

A

Features: CLOT

  • Coagulation defects
  • Livedo reticularis
  • Obstetric problems (recurrent miscarriage)
  • Thrombocytopenia

Management:

  • Antiplatelets, e.g. aspirin, clopidogrel
  • Anticoagulants, e.g. heparin, warfarin
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9
Q

Give three extra-articular features associated with ankylosing spondylitis

A
  • Anterior uveitis
  • Pulmonary fibrosis (commonly apical)
  • Aortic regurgitation (early diastolic murmur)
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10
Q

Give three radiological signs of ankylosing spondylitis on XR

A
  • Sacroiliitis
  • Squaring of the lumbar vertebrae
  • Bamboo spine
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11
Q

Give four subtypes of psoriasis

A
  • Chronic plaque
  • Guttate
  • Flexural
  • Pustular
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12
Q

What is the name of the complication of psoriatic arthritis which causes ‘telescoping’ of the joints in the hands?

A

Arthritis mutilans

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13
Q

Give four causes of reactive arthritis

A
  • Chlamydia
  • Campylobacter
  • Shigella
  • Salmonella
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14
Q

Reiter’s syndrome consists of a triad of…

A
  • Conjunctivitis
  • Urethritis
  • Arthritis
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15
Q

Small vessel vasculitis can be further classified as ANCA positive and ANCA negative. Give two examples of each

A

ANCA positive:

  • Churg-Strauss syndrome
  • Wegener’s granulomatosis with polyangiitis

ANCA negative:

  • Henoch-Schonlein purpura
  • Goodpasture’s syndrome
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16
Q

What is Raynaud’s phenomenon?

A

Peripheral digital ischaemia caused by vasospasm, precipitated by cold or emotion

17
Q

Raynaud’s phenomenon is associated with which other conditions?

A
  • RA
  • SLE
  • Cold agglutinin disease (AKA cold autoimmune haemolytic anaemia)
18
Q

Give two signs on examination which you may find in a patient with polymyositis/dermatomyositis?

A
  • Heliotrope (red/purple discolouration of eyelids)

- Gottron’s papules (red papules over knuckles)

19
Q

Polymyositis and dermatomyositis are associated with which autoantibodies?

A

Anti-Jo-1

Anti-Mi-2