Rheumatology

Question 1

Extraarticular manifestations of Rheumatoid Arthritis

Answer 1

• Rheumatoid nodules (on extensor surfaces & pressure points)
• Ocular (episcleritis, scleritis & scleromalacia perforans)
• Pulmonary (pleural disease, ILD, bronchiolitis obliterans, pulmonary nodules)
• Cardiac (pericarditis, myocarditis, conduction defects)
• Hematologic (IDA, Felty syndrome [splenomegaly, neutropenia & leg ulcers], high or low platelets, Non-Hodgkin lymphoma)
• Neurologic (atlantoaxial instability/subluxation), peripheral neuropathy, ischemia associated with vasculitis
• Rheumatoid vasculitis (leukocytoclastic, cutaneous ulcers)

Question 2

Rheumatologic conditions causing instability and subluxation of atlantoaxial joint?

Answer 2

Rheumatoid arthritis & ankylosing spondylitis

Question 3

Sarcoidosis epidemiology, pathophysiology, presentation & management

Answer 3

• epi: 20-60 yo; AA at increased risk, disease onset 10 years earlier
• path: multisystem noncaseating granulomatous disorder (T helper & inflammatory cells) of unknown etiology
• pres: fever, fatigue, weight loss, polyarthritis, cough, hemoptysis, DOE, Bell palsy, peripheral neuropathy, subQ nodules, lupus pernio, CHF, dysrythmias, uveitis, conjunctivitis, LAD