Rheumatology

Question 0

Saddle nose deformity

Answer 0

Wegeners
Relapsing polychondritis
Syphilis

Question 1

Diseases associated with anterior uveitis

Answer 1

Spondyloarthritis
Sarcoidosis
Behcet disease
JIA
Wegener's

Question 2

Anti-CCP antibodies

Answer 2

Rheumatoid arthritis

Question 3

Anti-Ro antibodies

Answer 3

Sjogren’s, Neonatal heart block

Question 4

Anti-La antibodies

Answer 4

Sjogren’s, Neonatal SLE

Question 5

p-ANCA

Answer 5

Churg-Strauss, microscopic polyangiitis

Question 6

Anti-myeloperoxidase antibodies

Answer 6

Churg-Strauss, microscopic polyangiitis

Question 7

Anti-proteinase-3 antibodies

Answer 7

Granulomatosis with polyangiitis (Wegener’s)

Question 8

c-ANCA

Answer 8

Granulomatosis with polyangiitis (Wegener’s)

Question 9

Anti-smooth muscle antibody

Answer 9

Autoimmune hepatitis

Question 10

Anti-centromere pattern of ANA

Answer 10

CREST/Limited cutaneous systemic sclerosis

Question 11

Anti-dsDNA

Answer 11

SLE

Question 13

Anti-Jo 1 antibody

Answer 13

Polymyositis

Question 14

Anti-RNP antibody

Answer 14

Mixed connective tissue disease

Question 15

Anti-scl-70 antibody (Anti-topoisomerase)

Answer 15

Scleroderma/Diffuse cutaneous systemic sclerosis

Question 16

Treatment for dermatomyositis

Answer 16

High-dose steroids

IF REFRACTORY: methotrexate, azathioprine, IVIg
For cutaneous manifestations: hydroxychloroquine

Question 17

Treatment of fibromyalgia

Answer 17

Pregabalin, SNRIs (duloxetine)

Question 18

Anti-cardiolipin antibody

Answer 18

Anti-phospholipid syndrome

Question 19

β2 glycoprotein I antibody assay

Answer 19

Anti-phospholipid syndrome

Question 20

dilute Russell viper venom time

Answer 20

Anti-phospholipid syndrome

Question 21

Flowing osteophytes along the anterolateral aspect of at least four contiguous vertebral bodies

Answer 21

Diffuse idiopathic skeletal hyperostosis

Question 22

Two types of cryoglobulinemia

Answer 22

Type 1: Monoclonal with paraproteins (e.g. Sjogren’s)

Type 2: Mixed/monoclonal - usually with active Hep C infection

Question 23

Causes of erythema nodosum

Answer 23

• Pregnancy
• Sarcoidosis
• IBD
• Collagen vascular disorders (dermatomyositis, SLE, scleroderma)
• Malignancy
• Sweet syndrome
• Behcet disease

Question 24

TNF-alpha inhibitors

Answer 24

Etanercept, infliximab, adalimumab

Associated with drug-induced lupus

Question 25

Drug requiring annual ophtho follow-up; may cause corneal disorder/retinopathy

Answer 25

Hydroxychloroquine

Question 26

Anti-Smith antibodies

Answer 26

SLE (most specific)