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orthopaedics > rheumatoid arthritis > Flashcards

rheumatoid arthritis Flashcards

1
Q

which HLA is rheumatoid associated with ?

A

HLADR4

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2
Q

when is peak incidence of RA?

A

in 50s

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3
Q

what do you get in bone which is different in RA vs OA?

A

erosion

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4
Q

how long do DMARDS take to get maximum effect?

A

can take up to 6 months

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5
Q

first line DMARD?

A

methotrexate

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6
Q

side effects of methotrexate ?

A

pulmonary fibrosis
bone marrow suppression
renal failure
hepatotoxicity

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7
Q

2nd line treatment ?

A

sulfasalazine

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8
Q

side effects of low sperm count ?

A

liver toxicity
bone marrow suppression
oligospermia (low sperm count)

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9
Q

when can you use anti TNF drugs?

A

only if two drugs have failed - one of them being methotrexate

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10
Q

side effect of penicillamine?

A

nephrotic syndrome

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11
Q

side effects of azathioprine ?

A

hepatotoxicity

bone marrow suppression

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12
Q

side effects of gold?

A

nephrotic syndrome

skin reaction

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13
Q

what class of drug is hydroxychloroquine?

A

anti malarial

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14
Q

side effects of hydroxychloroquine?

A

corneal micro deposits
retinopathy
tinnitus

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15
Q

side effects of hydroxychloroquin?

A 
farcry 
affects eyes and ears 
corneal micro deposits 
retinopathy 
tinnitus
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16
Q

name 3 anti TNF drugs

A

etanercept, adilumimab, infliximab

17
Q

anti TNF side effects?

A

blood dyscarias
REACTIVATION OF TB
anaphylaxis

18
Q

leflunomide side effects?

A

high blood pressure
myelosuppresion
weight loss

19
Q

which DMARD can exacerbate myasthenia gravis?

A

penicillamine

20
Q

which drugs cause bronchospasm in asthmatics?

A

NSAIDS

orthopaedics (17 decks)

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