rheumatoid arthritis Flashcards
1. properties of normal synovial membrane (synovium) 2.composition of normal synovial fluid 3.testing viscoeslastic properties of synovial fluid 4.pathophysiology of RA (+how it differs from OA) 5.Pannus (+treatment) 6.synovial fluid in RA 7. Treatment of RA
what are the components of the synovial membrane (synovium)?
- synovial fluid ultrafiltrate of blood
- loose areolar C.T
- synoviocytes
- subintima
where is synovial membrane found?
it is the SOFT TISSUE found between the jont capsule and articular cartilage
how does the ultrafiltrate of blood enter the synovial fluid?
through the subintima - contains dense network of fenestrated capillaries
what is the function of the synovial membrane?
forms a thin film over the surfcaes within articualr capusle (1-2ml only)
what are the 2 types of synviocytes?
type A + type B
which type of synoviocyte is for immune surveillance and what cell are they derived from?
type A - bone marrow derived macrophage
which type of synviocyte is found more abundantly + cell derivative + function?
type B - fibroblast like C.T cell
- synthesis of hyaluronic acid (hyaluronan)
what function does hyaluronic acid add to snyovial membrane?
- gel like property to synovial fluid
- secreted into joint cavity to :
- increase the viscosity + elasticity of articular cartilages
- lubricate the surfaces between synovium + cartilage.
how many layers thick is the normal synovium?
1-3 cell layers thick
what is the property of the synovium which allows the free of fluid between the joint capsule and articular cartilage?
no basement membrane with the subintima
