rheumatoid arthritis Flashcards

1. properties of normal synovial membrane (synovium) 2.composition of normal synovial fluid 3.testing viscoeslastic properties of synovial fluid 4.pathophysiology of RA (+how it differs from OA) 5.Pannus (+treatment) 6.synovial fluid in RA 7. Treatment of RA

1
Q

what are the components of the synovial membrane (synovium)?

A
  1. synovial fluid ultrafiltrate of blood
  2. loose areolar C.T
  3. synoviocytes
  4. subintima
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2
Q

where is synovial membrane found?

A

it is the SOFT TISSUE found between the jont capsule and articular cartilage

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3
Q

how does the ultrafiltrate of blood enter the synovial fluid?

A

through the subintima - contains dense network of fenestrated capillaries

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4
Q

what is the function of the synovial membrane?

A

forms a thin film over the surfcaes within articualr capusle (1-2ml only)

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5
Q

what are the 2 types of synviocytes?

A

type A + type B

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6
Q

which type of synoviocyte is for immune surveillance and what cell are they derived from?

A

type A - bone marrow derived macrophage

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7
Q

which type of synviocyte is found more abundantly + cell derivative + function?

A

type B - fibroblast like C.T cell

- synthesis of hyaluronic acid (hyaluronan)

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8
Q

what function does hyaluronic acid add to snyovial membrane?

A
    • gel like property to synovial fluid
  1. secreted into joint cavity to :
    • increase the viscosity + elasticity of articular cartilages
    • lubricate the surfaces between synovium + cartilage.
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9
Q

how many layers thick is the normal synovium?

A

1-3 cell layers thick

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10
Q

what is the property of the synovium which allows the free of fluid between the joint capsule and articular cartilage?

A

no basement membrane with the subintima

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