Inflammatory joint disorders Flashcards
word for single joint pain
monoarthralgia
word for mutliple joint pain
polyarthralgia
conditions associated with polyarthralgia
AUTOIMMUNE JOINT DISEASES
- RA
- C.T disorders
- Spondyloarthritis
conditions associated with monoarthralgia
- crystal arthropathy (gout,psudeogout)
- infection
- degenerative disorder (OA)
RA
- prevalence
- incidence
- gender
- peak onset
- 1% pop
- 12,000 new cases per year
- females (3:1)
- 20-50yrs
RA
- joints commonly affected
- clinical features
- MCP +PIP of wrist (+ knees + ankles + feet)
- symmetrical polyarthralgia + early morning stiffness
RA hands
- early stage
- intermediate stage
- late stage
- erythema + swelling + warmth + tender MCP
- swan neck deformity + boutinnere deformity
- rheumatoid nodules + ulnar deviation + sublax phalanges
RA knees
- valgus deformity
2. bakers cyst (calf muscles)
RA occular complications
RA affects mucous membranes not just synovium
- keratoconjuncttivitis sicca (no tears - dry eyes)
- scleritis
scleritis - intracoccular content herniates - SCLEROMALACIA PERFORANS
RA neuromuscular complications in hand
CARPAL TUNNEL SYNDROME
- median nerve entrapment
- test = phalen’s /tinel’s
- thenar eminence wastage
- numbness of thumb/1st 2 fingers
RA neuromusclar complication spinal cord
ATLANTO-AXIAL SUBLUXATION
- NECK PAIN = red flag
- exc movement between C1 + C2 -damages SC
- UMN signs in legs = babinksi,spasticity, hyperflexia
can lead to death
Reason for mortality in RA patients
IHD - reduces L.E 10years
Systemic complications in RA
- cardiac
- bone
- IHD, pericarditis, nodules
2. accelerated osteoporosis
Pathology RA
- hypertrophy of synovium - pannus - cartilage destruction + bone exposed
- infiltration of immune cells - mass pro-inflammatory cytokine release - cartilage + bone destruction
what rheumatoid factor (RF)
autoantibody to Fc portion of IgG