DRUG LIST Flashcards
Osteoprotegrin (OPG)
decoy receptor for RANKL - prevents osteoclast activation
glucorticosteroids
prolonged use - OSTEOPOROSIS
(bone resorption increased + calcium absorption gut decreased
raloxifene
SERM
- selective oestrogen receptor modulator
- increases oestrgenic actions in bone - reduces bone turnover-slows osteoporosis
- only acts in BONE (not breast/uterus-malignancy)
FOR OSTEOPOROSIS
BISPHOSPHONATES
- administration
- MOA
- name 5
- oral
- osteoclast apoptosis + decrease RANKL expression
- ALEN/RISE/IBAN/PAMI/ZOLE-dronate
FOR OSTEOPOROSIS
teriparatide
recombinant PTH
- stimulates Ca resorption bone + kidneys
- stimulates osteoblast - osteoclast activity
- stimulates active vit D formation
FOR OSTEOPOROSIS (severe cases)
denosumab
=monoclonal antibody for RANKL
=SC injection (6monthly)
(prevents RANK binding to RANKL on osteoclasts)
prevents OSTEOCLAST ACTIVITY
FOR OSTEOPOROSIS
Treatment for inflammatory myopathies
- corticosteroids (until CK levels normal)
2. adjunctive therapy = MTX + AZT
Treatment for fibromyalgia
- TCAs
- SSRIs
- exercise
Strontium ranelate
OSTEOPOROSIS
-strontium-similar size to calcium -taken up by bones
-MOA
=decreases bone resorption + increase Ca absorption gut
=stimulates osteoblasts secrete (OPG)
colchicine
GOUT
inhibits:
-microtubule formation - mitosis
-neutrophil motility + proliferation
riloncept
GOUT (+RA)
IL-1 blocker
DIMERIC fusion protein - IL1R + Fc of HUMAN IgG1
anakinra
GOUT (+RA)
- human recombinannt IL1 receptor antagonist
- binds IL-1R
- SC injection
allopurinol
CHRONIC GOUT
xanthine oxidase inhibitor
rasburicase
CHRONIC GOUT
catalytic enzyme =xanthine- allantoin -more soluble
probenecid
CHRONIC GOUT
uricosuric - increase renal excretion uric acid
(less SE than allopurinol)
treatment pseudogout
intra-articular corticosteroid + NSAIDs
ASPIRIN
action + SE
CARDIOVASCULAR
3A= anti-inflammatory + analgesic + antipyretic
delays labour + antiplatelet aggr
SE= peptic ulcers + hyperuricaemia