Rheumatic Diseases

Question 1

Rheumatic

Answer 1

Migratory nature of the pain

Question 2

CT and collagen

Answer 2

Components typically involved in rheumatic disease

Question 3

In rheumatic disease, what is the dual relevance of collagen

Answer 3

Target for autoimmune reactions and as a component of connective tissue produced in excess

Question 4

Clinical manifestations of rheumatic disease

Answer 4

Joints and muscles

But can also be other like SLE and ankylosing spondylitis

Question 5

SLE

Answer 5

Systemic manifestations frequently predominate over those localized to the joints

Question 6

Anyylosing spondylitis

Answer 6

Particular region, the sacroilium

Question 7

SLE indications

Answer 7

Multisystem disease that follows a fluctuating course, with exacerbation and spontaneous remissions
Variety of circulating autoantibodies

Question 8

What particular autoantibodies are in SLE

Answer 8

Directed against components of the cell nucleus play a pivotal diagnostic and pathological role

Question 9

What populations have high SLE

Answer 9

Afro-carribean and orientals women of childbearing age

Question 10

What allele in Caucasian’s increases risk of SLE

Answer 10

HLA class II DRB1*0301 (DR3)

Question 11

HLA gene for SLE in orientals

Answer 11

DRB1*1501 (DR2)

Question 12

The role of genes in causation of the disease is indicated by the higher concordance for SLE in

Answer 12

Monoxygotic when compared with dizygotic twins

Question 13

Pathology of SLE

Answer 13

Renal failure
Immune complex (deposition) by immunofluoreence 
Also seen at dermoepidermal junction int he skin

Question 14

Pathogenesis of SLE

Answer 14

Environmental and susceptibility genes to produce an overactive, autoaggressive immune response