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Immunology > Dr In Training > Flashcards

Dr In Training Flashcards

1
Q

MHC

A

Allow leukocytes and cels to communicate

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2
Q

Mhc1

A

On all nucleated cells, antigen presenting cells, platelets, never RBC

Willl present self or antigen

HLA-A, B, C

Presents antigen synthesized endogenously

One long chain a1,a2,a3
One short b1

Peptide bingeing groove between a1,q2

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3
Q

MHCII

A

On antigen presenting cell

Loci is HLA-DP, all have two letters

Bind CD4

Present non endogenous

2 equal chain, a1, a2, b1, b2

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4
Q

Loaded after invariant chain is acidified in endosomes

A

Class II

MHC I loaded through RER

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5
Q

APC

A

TH1, TH2, TH17, Treg

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6
Q

What activates TH1

A

IFN-y, IL12

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7
Q

What does TH1 make

A

IFN-y

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8
Q

What does TH1 activate

A

Macrophages, cytotoxic T cells

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9
Q

Problem with TH1

A

Increased susceptibility to microbacterial diseases

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10
Q

What activate TH2

A

IL2, IL4

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11
Q

Where are TH2

A

Mucosa gut and nasal passages

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12
Q

What TH2 secrete

A

IL4, 5, 6, 10, 13

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13
Q

What TH2 activate

A

Eosinophils and promote IgE for nasty worms

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14
Q

What makes TH17

A

TGFB, IL6,

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15
Q

What TH17 make

A

IL17, 21, 22

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16
Q

Job TH17

A

Recruit neutrophils for fungal and bacterial cells

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17
Q

Treg

A

Keep other cells from getting ahead

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18
Q

What induce Treg

A

TGFB, IL12

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19
Q

What T reg make

A

TGFB, IL10, IL35

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20
Q

IL4 IL10 from TH2

A

Inhibit TH1

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21
Q

IFNy from TH1

A

Inhibit TH1 and TH17

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22
Q

IL6 from TH2

A

Inhibits T reg

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23
Q

T cell precursor

A

In bone marrow

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24
Q

Where T cell go to mature

A

Thymus

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25
Q

In thymic cortex

A

Positive selection -assures T cell can bind MHC and if better with class I or 2

Class I CD8

MHC2 CD4

26
Q

One differentiated

A

Moves to medulla for negative selection

27
Q

Negative selection

A

Strong bind self antigen-apoptosis, AIRE allows tissue restricted self antigens to be expressed (with out Polyendocrine immune syndrome1)

28
Q

CD8

A

Cytotoxic kill virus infected, neoplastic, and donor graft cells

29
Q

CD4

A

Helper and differentiate into subsets

30
Q

IL1

A

Fever and acute inflammation hen come in contact with pathogen-generalized inflammation

Chemokine secretion to get more wbc

31
Q

IL6

A

Fever

Stimulates acute phase protein(increase CRP)

32
Q

Il8

A

Main chemotactic factor for neutrophils

-clean up isle 8

33
Q

Interleukin 12

A

Induces differentiation

Activates NK cells

34
Q

TNFa

A

Activates endothelium and vascular leak (can lead to hypotension and shock)

35
Q

Those were macrophages

A

Ok

36
Q

T cell

A

IL2 IL3

37
Q

IL2

A

Stimulates growth of helper T cells and cytotoxic T cells

38
Q

IL3

A

Supports growth and differentiation of bone marrow in stem cells

39
Q

TH1

A

IFNy

40
Q

IFNY

A

Stimulates macrophages, inhibits TH2 cells, activating NK (antiviral)

41
Q

TH2

A

IL4, 5, 13

42
Q

IL4,

A

Induces T cells->TH3

Promotes growth of B cells

Promotes class switching of IgE->IgG

Ain’t too proud 2 BEG 4 work

43
Q

IL5

A

Promotes growth and differentiation of B cells

Enhances switching to IgA

Stimulates growth and differentiation of eosinophils

44
Q

IL10

A

Modulates inflammatory response

Decrease MHCII and TH1 cytokines

Inhibits macrophages and dendritic cells

Secreted by Treg and TH2

45
Q

HOT T Bone steak

A

Il1 hot
Il2 stilate T cell
IL3 stimulate bone marrow for more leukocytes
IL4 IgE production
Il5 IgA production
IL6 stimulate aKute phase protein production

46
Q

Leukocyte extravasation

A

Getting wbc out of bloodstream and into tissues

4 steps

47
Q

1

A

Neutrophil sticky ROLLING on vascular endothelium, bounding , rolling and endothelium can select by selectin

48
Q

E selectin

A

Endothelial cells

49
Q

P selectin

A

Platelets

50
Q

L selectin

A

Leukocytes

51
Q

Are selectin always expressed

A

No acute phase cytokine il1, 6, TNFa make endothelial cells stickier a

52
Q

Step 2

A

Tight binding

ICAM-1 on endothelial cells LFA1 on leukocytes (integrin)

53
Q

Step 3

A

Diapedesis

54
Q

Leukocyte go in between PECAM1 in intracellular junctions go through

A

Ok

55
Q

Step 4

A

Migration

Through interstitial to place need to go based on chemotactic signals

56
Q

Neutrophil chemotactic factos

A

C5a IL8, LTB4, kallirein

57
Q

Ataxia-telangiectasia

A

Defective DNA repair

Ataxic gait facial telangiectasis

Poor smooth pursuit with the eyes

Elevated AFP

58
Q

Bruton agammaglobuliminemia

A

X linked tyrosine kinase defiency

Low levels of all IgG isotopes

59
Q

Digeorge disease

A

2q11 deletion

Defective development of 3rd and 4th branchial pouches

Hypocalcemia

Thymic aplasia

60
Q

SCID

A

Defective DNA repairadenosine deaminase defiency

Infections, diarrhea, failure to thrive

Thymic aplasia (absent thymic shadow on new born )

Immunology (14 decks)

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