Rheum

Question 1

Systemic sclerosis

Answer 1

Unknown cause
Characterized by thickening of skin and involvement of multiple internal organs
Common presenting symptom = Raynaud’s, carpal tunnel, pruritus, edematous hands/face, arthralgias –> tensing skin, loss of skin creases, loss of body hair, dry skin

Question 2

Antibody a/w systemic sclerosis

Answer 2

Antitopoisomerase antibody test

Question 3

Sclerodermal renal crisis a/w which drug

Answer 3

Glucocorticoid

Question 4

Allopurinol

Answer 4

Blocks xanthine oxidase which reduces generation of uric acid
Used in gout pts who overproduce uric acid

Question 5

Probenecid

Answer 5

Used in pts who undersecrete uric acid
May be combined with allopurinol in pts with resistant hyperuricemia
Must have CrCl > 60

Question 6

Mild RA tx

Answer 6

MTX

Question 7

Moderate to severe RA Tx

Answer 7

MTX with rapid move to triple therapy
MTX + Sulfasalazine + hydroxychloroquine
May need bridging with glucocoricoids
May need step up to biologics - anti-TNF (adalinumab), antiCD20 (rituximab), anti-costimulatory molecules (abatacept)

Question 8

RA drug that actually slows progression

Answer 8

Hydroxychloroquine

Question 9

PMR treatment

Answer 9

Prednisone

Question 10

OA clinical dx

Answer 10

Persistent usage related joint pain in 1 or few joints
Age >/= 45yo
Morning stiffness = 30min

Question 11

DIP sparing arthritis

Answer 11

Rheumatoid