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BBLec Sumaya > RH Blood Group System > Flashcards

RH Blood Group System Flashcards

1
Q

It completes the correct phenotype of the Rh system

A

D, C,c,E,e

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2
Q

It is highly immunogenic

A

Rh Antigens

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3
Q

T/F
There is a regular presence of Anti-rh in serum?

A

False

No regular presence of anti-Rh in serum.

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4
Q

Rh antibodies are what type in nature?

A

Immune type

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5
Q

They used rhesus monkey red cells to the guinea pigs and rabbits.

A

Landsteiner and Wiener

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6
Q

Who 1st discovered Rh blood group system

A

Levine and Stetson

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7
Q

The antibodies discovered by Landsteiner were given the name

A

Anti-LW

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8
Q

Consists the Rh-Hr nomenclature.

A

Wiener

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9
Q

What are the five major antigens in Wiener are

A

Rho, rh’, rh’’, hr’, hr’’

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10
Q

Consists the CDE/cde nomenclature.

A

Fisher-Race

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11
Q

What are the 5 major antigens are in Fisher-Race defined as

A

D,C,c,E,e

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12
Q

This has no genetic background

A

Rosenfield

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13
Q

Rh antigens are assigned numbers to correspond to antigens already designated by other nomenclature.

A

Rosefield

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14
Q

This Utilizes numeric terminology where each known system is given a number.

A

International Society of Blood Transfusion

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15
Q

Each antigen within a system is numbered sequentially in the order of discovery.

A

ISBT

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16
Q

In ISBT, First 3 numbers represent the

A

System

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17
Q

In ISBT, the last 3 numbers represent the

A

Antigenic Specificity

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18
Q

What is the current theory by Tippett

A

Two closely linked gene theory

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19
Q

In the theory of Tippett, genes are located at what chromosome?

A

Chromosome #1

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20
Q

There are two gene loci in the theory of Tippett, these are the

A

RHD, RHCE

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21
Q

The first gene locus, codes for the presence or absence of D

A

RHD

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22
Q

The second gene locus, codes for either Ce, cE, ce, or CE.

A

RHCE

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23
Q

What gene is Non existent?

A

d gene

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24
Q

This gene resides at Chromosomes no.6

A

RH associated glycoprotein/ RHAG

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25
This is very similar to the Rh protein structure, and within the RBC membrane it forms complexes with the Rh polypeptides.
RHAG
26
This is called co-expressor. Required for the successful expression of the Rh antigens
RHAG
27
The three closely linked gene theory is by
Fisher-Race
28
This theory wherein, Antigens are inherited as three closely linked sets of alleles.
Three Closely Linked Gene Theory
29
THREE CLOSELY-LINKED GENE THEORY BY FISHER-RACE, consist of how many loci, and these are?
3 loci Dd gene, Cc, gene, Ee gene
30
T/F Letters in the genotype are written only once as they appear, example, you don’t write “ee”, but only single “e” in the genotype.
False, it should be phenotype
31
Multiple allele theory is by
Wiener
32
Rh antigens are inherited as products of single genes at single loci.
MULTIPLE ALLELE THEORY BY WIENER
33
More than one blood factor characterize the Rh antigen
MULTIPLE ALLELE THEORY BY WIENER
34
A minus sign preceding a number designates the absence of the antigen.
Rosenfield
35
Gives characteristics of RH Antigens
Rh Ag are proteins, found only on red cells, immunogenic,
36
This antigen is most clinically significant. It is most highly immunogenic. The only antigen tested for in routine typing
D antigen
37
What antigen results when some of the component parts are missing. This is called as?
Incomplete D/Partial D D mosaic
38
What reaction is Incomplete D or Partial D
False negative reaction
39
This occur when 2 Rh genes are on the same chromosome
Compound antigen
40
This lack alleles at the Ee locus or at the Ee and Cc loci; and associated with unusually strong D antigens.
D-deletion genes
41
D-deletion genes from anti-?
Anti-Rh 17
42
RBCs lack all Rh antigens including Rh29.
Rhnull
43
What Rh is present to all RBCS
Rh29
44
The lack of Rh antigens results in
Stomatocytes
45
This is weakened form of D antigen
Du Antigen
46
These patients must be tested for Du
D negative donors and obstetric patients
47
D negative donors and obstetric patients must be tested for Du, by what type of testing
Indirect AHG or Weak D testing
48
Du positive recipients should always receive what type of blood
D-negative blood
49
Du is inherited in 3 ways
As incomplete Antigen or D mosaic Due to position effect Genetic coding of Weakened D expression
50
The genes for C and c are
Codominant
51
What Rh is c-like antigen
Rh-26
52
Rh26 is seen often and found on almost
C-pos cells
53
The E and e antigen expression are
Codominant
54
T/F E antigen is immunogenic than e antigen
True
55
Immunogenecity
D>c>E>C>e
56
produced by the same Rh gene complex that produce C and D antigens. Most C-pos and D-pos are G positive.
G antigen
57
Appear as immune antibody, produced by red cell stimulation
Rh Antibodies
58
Rh Abs, appear between how many weeks and months after exposure to Rh antigen.
6wks, 6 mos
59
Rh Abs are mostly what type of IgG
IgG1, IgG3
60
Do not agglutinate in saline unless there is major IgM component
Rh Abs
61
Rh Abs, React best at 37C, and demonstrated by
High protein medium and Indirect AHG testing
62
T/F Rh Abs do not usually bind to complement
True
63
T/F Rh Abs Can cross the placenta and cause HDN.
True
64
Phenotypically similar with Rh system
LW Ag and Ab
65
May appear as autoantibody; seen occasionally in AIHA.
LW AG AND AB
66
HTR resulted to
Hepatosplenomegaly Anemia ^ Jaundice Decreased in hematocrit
67
T/F In modern times, C,D,E antigens are primary used while Rho, rh’ are used secondarily.
True
68
TRUE or FALSE: The DCcEe are codominant?
True
69
Why does DCcEe are codominant
When gene are found on chromosome locus, they will be all expressed on the RC
70
What gene combination is most prevalent among Blacks
Dce
71
What gene combination is highest among Asian,and Whites
DcE
72
The location of two or more genes on the same chromosome of a homologous pair.
Cis

BBLec Sumaya (6 decks)

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