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BBLec Sumaya > RH Blood Group System > Flashcards

RH Blood Group System Flashcards

1
Q

It completes the correct phenotype of the Rh system

A

D, C,c,E,e

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2
Q

It is highly immunogenic

A

Rh Antigens

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3
Q

T/F
There is a regular presence of Anti-rh in serum?

A

False

No regular presence of anti-Rh in serum.

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4
Q

Rh antibodies are what type in nature?

A

Immune type

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5
Q

They used rhesus monkey red cells to the guinea pigs and rabbits.

A

Landsteiner and Wiener

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6
Q

Who 1st discovered Rh blood group system

A

Levine and Stetson

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7
Q

The antibodies discovered by Landsteiner were given the name

A

Anti-LW

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8
Q

Consists the Rh-Hr nomenclature.

A

Wiener

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9
Q

What are the five major antigens in Wiener are

A

Rho, rh’, rh’’, hr’, hr’’

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10
Q

Consists the CDE/cde nomenclature.

A

Fisher-Race

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11
Q

What are the 5 major antigens are in Fisher-Race defined as

A

D,C,c,E,e

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12
Q

This has no genetic background

A

Rosenfield

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13
Q

Rh antigens are assigned numbers to correspond to antigens already designated by other nomenclature.

A

Rosefield

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14
Q

This Utilizes numeric terminology where each known system is given a number.

A

International Society of Blood Transfusion

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15
Q

Each antigen within a system is numbered sequentially in the order of discovery.

A

ISBT

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16
Q

In ISBT, First 3 numbers represent the

A

System

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17
Q

In ISBT, the last 3 numbers represent the

A

Antigenic Specificity

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18
Q

What is the current theory by Tippett

A

Two closely linked gene theory

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19
Q

In the theory of Tippett, genes are located at what chromosome?

A

Chromosome #1

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20
Q

There are two gene loci in the theory of Tippett, these are the

A

RHD, RHCE

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21
Q

The first gene locus, codes for the presence or absence of D

A

RHD

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22
Q

The second gene locus, codes for either Ce, cE, ce, or CE.

A

RHCE

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23
Q

What gene is Non existent?

A

d gene

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24
Q

This gene resides at Chromosomes no.6

A

RH associated glycoprotein/ RHAG

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25
Q

This is very similar to the Rh protein structure, and within the RBC membrane it forms complexes with the Rh polypeptides.

A

RHAG

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26
Q

This is called co-expressor. Required for the successful expression of the Rh antigens

A

RHAG

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27
Q

The three closely linked gene theory is by

A

Fisher-Race

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28
Q

This theory wherein, Antigens are inherited as three closely linked sets of alleles.

A

Three Closely Linked Gene Theory

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29
Q

THREE CLOSELY-LINKED GENE THEORY BY FISHER-RACE, consist of how many loci, and these are?

A

3 loci
Dd gene, Cc, gene, Ee gene

30
Q

T/F

Letters in the genotype are written only once as they appear, example, you don’t write “ee”, but only single “e” in the genotype.

A

False, it should be phenotype

31
Q

Multiple allele theory is by

A

Wiener

32
Q

Rh antigens are inherited as products of single genes at single loci.

A

MULTIPLE ALLELE THEORY BY WIENER

33
Q

More than one blood factor characterize the Rh antigen

A

MULTIPLE ALLELE THEORY BY WIENER

34
Q

A minus sign preceding a number designates the absence of the antigen.

A

Rosenfield

35
Q

Gives characteristics of RH Antigens

A

Rh Ag are proteins, found only on red cells, immunogenic,

36
Q

This antigen is most clinically significant. It is most highly immunogenic. The only antigen tested for in routine typing

A

D antigen

37
Q

What antigen results when some of the component parts are missing.
This is called as?

A

Incomplete D/Partial D
D mosaic

38
Q

What reaction is Incomplete D or Partial D

A

False negative reaction

39
Q

This occur when 2 Rh genes are on the same chromosome

A

Compound antigen

40
Q

This lack alleles at the Ee locus or at the Ee and Cc loci; and associated with unusually strong D antigens.

A

D-deletion genes

41
Q

D-deletion genes from anti-?

A

Anti-Rh 17

42
Q

RBCs lack all Rh antigens including Rh29.

A

Rhnull

43
Q

What Rh is present to all RBCS

A

Rh29

44
Q

The lack of Rh antigens results in

A

Stomatocytes

45
Q

This is weakened form of D antigen

A

Du Antigen

46
Q

These patients must be tested for Du

A

D negative donors and obstetric patients

47
Q

D negative donors and obstetric patients must be tested for Du, by what type of testing

A

Indirect AHG or Weak D testing

48
Q

Du positive recipients should always receive what type of blood

A

D-negative blood

49
Q

Du is inherited in 3 ways

A

As incomplete Antigen or D mosaic
Due to position effect
Genetic coding of Weakened D expression

50
Q

The genes for C and c are

A

Codominant

51
Q

What Rh is c-like antigen

A

Rh-26

52
Q

Rh26 is seen often and found on almost

A

C-pos cells

53
Q

The E and e antigen expression are

A

Codominant

54
Q

T/F
E antigen is immunogenic than e antigen

A

True

55
Q

Immunogenecity

A

D>c>E>C>e

56
Q

produced by the same Rh gene complex that produce C and D antigens. Most C-pos and D-pos are G positive.

A

G antigen

57
Q

Appear as immune antibody, produced by red cell stimulation

A

Rh Antibodies

58
Q

Rh Abs, appear between how many weeks and months after exposure to Rh antigen.

A

6wks, 6 mos

59
Q

Rh Abs are mostly what type of IgG

A

IgG1, IgG3

60
Q

Do not agglutinate in saline unless there is major IgM component

A

Rh Abs

61
Q

Rh Abs, React best at 37C, and demonstrated by

A

High protein medium and Indirect AHG testing

62
Q

T/F
Rh Abs do not usually bind to complement

A

True

63
Q

T/F
Rh Abs Can cross the placenta and cause HDN.

A

True

64
Q

Phenotypically similar with Rh system

A

LW Ag and Ab

65
Q

May appear as autoantibody; seen occasionally in AIHA.

A

LW AG AND AB

66
Q

HTR resulted to

A

Hepatosplenomegaly
Anemia
^ Jaundice
Decreased in hematocrit

67
Q

T/F

In modern times, C,D,E antigens
are primary used while Rho, rh’
are used secondarily.

A

True

68
Q

TRUE or FALSE: The DCcEe
are codominant?

A

True

69
Q

Why does DCcEe are codominant

A

When gene are found on chromosome locus, they will be all expressed on the RC

70
Q

What gene combination is most prevalent among Blacks

A

Dce

71
Q

What gene combination is highest among Asian,and Whites

A

DcE

72
Q

The location of two or more genes on the same chromosome of a
homologous pair.

A

Cis

BBLec Sumaya (6 decks)

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