ABO Flashcards
(54 cards)
He discovered the first human blood group system→Types A, B, O.
Karl Landsteiner
Discovered Type AB
Von Decastello, Sturli
described the first theory of inheritance of ABO, follows the simple Mendelian genetics.
Bernstein
discovery of A1 and A2 subgroups
Thompson
Landsteiner Rule on Ags and Ab
-Blood group antigens found on the RBC membrane identifies the blood type.
-Antibodies in plasma (serum) are reciprocal to the antigens.
The most important of all blood group systems in transfusion practice.
ABO BLOOD GROUP SYSTEM
The only system where antibodies are predictably (expected) found in plasma/ serum and reciprocal to antigens on RBCs.
Abo blood group system
Transfusion due to incompatible antibodies can result to
immediate lysis of red cells→serious fatal transfusion reaction.
It is the foundation on which all other pretransfusion testing is based.
Abo incompatibility between donor and patient
Blood types can be determined by?
Forward and Reverse Typing
ABO antigens are found on tissue cells→important in
Tissue/ Organ transplant
ABO and H antigens are secreted into body fluids by
Secretors
Chromosome of ABO genes
Chromosomes 9
A and B genes are
Autosomal codominant
O genes is
Amorph and recessive
What are the other genes that interact with ABO genes locus at chromosome # 9:
H, Le, Se, I, and P
The ABO genes do not code directly for the antigens, but instead, they code for the production of enzymes
Glycosyltransferases
which are involved in the formation of respective antigenic determinants (epitopes of antigens).
Glycosyltransferases
Not able to bring out the production of active enzyme
Gene O
What gene present in more than 99.99% of random population.
H gene
What is the immunodominant sugar of A gene
N-acetylgalactosamine
What is the immunodominant sugar of H
L-fucose
What is the immunodominant sugar of B
Galactose
What enzymes are coded for H gene
Fucosyl transferase
