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BBLec Sumaya > ABO > Flashcards

ABO Flashcards

1
Q

He discovered the first human blood group system→Types A, B, O.

A

Karl Landsteiner

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2
Q

Discovered Type AB

A

Von Decastello, Sturli

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3
Q

described the first theory of inheritance of ABO, follows the simple Mendelian genetics.

A

Bernstein

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4
Q

discovery of A1 and A2 subgroups

A

Thompson

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5
Q

Landsteiner Rule on Ags and Ab

A

-Blood group antigens found on the RBC membrane identifies the blood type.
-Antibodies in plasma (serum) are reciprocal to the antigens.

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6
Q

The most important of all blood group systems in transfusion practice.

A

ABO BLOOD GROUP SYSTEM

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7
Q

The only system where antibodies are predictably (expected) found in plasma/ serum and reciprocal to antigens on RBCs.

A

Abo blood group system

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8
Q

Transfusion due to incompatible antibodies can result to

A

immediate lysis of red cells→serious fatal transfusion reaction.

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9
Q

It is the foundation on which all other pretransfusion testing is based.

A

Abo incompatibility between donor and patient

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10
Q

Blood types can be determined by?

A

Forward and Reverse Typing

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11
Q

ABO antigens are found on tissue cells→important in

A

Tissue/ Organ transplant

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12
Q

ABO and H antigens are secreted into body fluids by

A

Secretors

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13
Q

Chromosome of ABO genes

A

Chromosomes 9

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14
Q

A and B genes are

A

Autosomal codominant

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15
Q

O genes is

A

Amorph and recessive

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16
Q

What are the other genes that interact with ABO genes locus at chromosome # 9:

A

H, Le, Se, I, and P

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17
Q

The ABO genes do not code directly for the antigens, but instead, they code for the production of enzymes

A

Glycosyltransferases

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18
Q

which are involved in the formation of respective antigenic determinants (epitopes of antigens).

A

Glycosyltransferases

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19
Q

Not able to bring out the production of active enzyme

A

Gene O

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20
Q

What gene present in more than 99.99% of random population.

A

H gene

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21
Q

What is the immunodominant sugar of A gene

A

N-acetylgalactosamine

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22
Q

What is the immunodominant sugar of H

A

L-fucose

23
Q

What is the immunodominant sugar of B

A

Galactose

24
Q

What enzymes are coded for H gene

A

Fucosyl transferase

25
Q

What enzymes are coded for A gene

A

N-acetylgalactosaminyl transferase

26
Q

What enzymes are coded for B gene

A

Galactosyl transferase

27
Q

The precursor of A and B antigens

A

H antigen

28
Q

It does not elicit the production of catalytically active polypeptide.

A

O gene

29
Q

What blood group has the highest amount of H antigens on the red cells.

A

O blood group

30
Q

H antigen in decreasing amount

A

O>A2>B>A2B>A1>A1B

31
Q

ABH antigens begin to develop in the

A

5-6th weeks of fetal life

32
Q

ABH antigens are not well developed at birth(T/F)

A

True

33
Q

The presence of H substance in body secretions is controlled by the

A

Se genes

34
Q

How many percent of the population have secretor genes

A

80%

35
Q

attachment of galactose to terminal galactose of H substance.

A

B subtances

36
Q

attachment of fucose to terminal galactose of precursor substance.

A

H subtance

37
Q

attachment of N-acetylgalactosamine to terminal galactose of H substance.

A

A substance

38
Q

Group O secretor = has what substances in secretion

A

H substance

39
Q

Group A secretor = has what substances in secretion

A

A and H substance

40
Q

Group B secretor = has what substances in secretion

A

B and H subtances

41
Q

Individuals who are homozygous sese (do not have the Se gene) are

A

Nonsecretors

42
Q

Starts to develop shortly after baby is born

A

Abo antibodies

43
Q

Not able to develop the H antigen from the precursor antigen.

A

Bombay phenotype

44
Q

they are not able to develop, as well, the A and B antigens

A

Bombay phenotype

45
Q

Bombay phenotype discovered by

A

Bhende in Bombay, now in Mumbai India

46
Q

H antigens weakly expressed on RBC

A

Parabombay phenotype

47
Q

H antigens may be present in secretions but none on the
red cells

A

Parabombay phenotypes

48
Q

Reported to occur in Type O or Type B

A

Acquired A antigen

49
Q

Associated with aseptic infection with Proteus mirabilis

A

Acquired A antigen

50
Q

A rare phenomenon, associated with polyagglutination of
red cells.

A

Acquired A antigen

51
Q

patients with bacterial infections and often cancer of the colon or rectum

A

Acquired B antigen

52
Q

Weakly reacting or missing antibodies

A

Group 1

53
Q

weakly reacting or missing antigens

A

Group 2

54
Q

caused by protein or plasma abnormalities→ rouleaux formation of cells

A

Group III

BBLec Sumaya (6 decks)

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