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Blood Banking > Rh Blood Group > Flashcards

Rh Blood Group Flashcards

1
Q

Most complex red cell antigen system

A

Rh blood group

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2
Q

RhD and RhCE genes proposed by

A

Patricia Tippett

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3
Q

Location of RhD and RhCE gene

A

Chromosome 1

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4
Q

Location of RhAG gene

A

Chromosome 6

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5
Q

Controls expression of RhD, RhCe, RhcE, RhCE, Rhce

A

RhD and RhCE genes

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6
Q

Co-expressor but itself cannot express any Rh antigen

A

RhAG gene

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7
Q

Presence of 3 separate genes linked on the same chromosome and are inherited as a group of 3

A

Fisher-Race

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8
Q

A single locus on a gene carries entire Rh system

A

Weiner

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9
Q

DCE nomenclature

A

Fisher-Race

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10
Q

Rh-Hr Terminology

A

Wiener

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11
Q

DCe

A

R1

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12
Q

DcE

A

R2

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13
Q

DCE

A

Rz

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14
Q

dcE

A

r”

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15
Q

dCe

A

r’

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16
Q

dCE

A

ry

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17
Q

R0r

A

Dce/dCe

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18
Q

R1R2

A

DCe/DcE

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19
Q

R1r”

A

DCe/dcE

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20
Q

Rzr

A

DCE/dce

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21
Q

R2r’

A

DcE/dCe

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22
Q

r’r”

A

dCe/dcE

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23
Q

R0
Fisher-Race:
Blood factors:

A

Dce
Rh0hr’hr”

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24
Q

R1
Fisher-Race:
Blood factors:

A

DCe
Rh0rh’hr”

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25
Q

R2
Fisher-Race:
Blood factors:

A

DcE
Rh0hr’rh”

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26
Q

Rz
Fisher-Race:
Blood factors:

A

DCE
Rh0rh’rh”

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27
Q

r
Fisher-Race:
Blood factors:

A

dce
hr’hr”

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28
Q

r’
Fisher-Race:
Blood factors:

A

dCe
rh’hr”

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29
Q

r”
Fisher-Race:
Blood factors:

A

dcE
hr’rh”

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30
Q

ry
Fisher-Race:
Blood factors:

A

dCE
rh’rh”

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31
Q

Most common in Blacks

A

R0r

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32
Q

Most common in Asian/Whites

A

R1r

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33
Q

Four most common genotypes

A

R1, R2, r, R0

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34
Q

African-American common genotype

A

R0 > r > R1 > R2

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35
Q

Caucasians common genotype

A

R1 > r > R2 > R0

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36
Q

System that assigns a number to each antigen in order of its discovery or recognized relationship to Rh system

A

Rosenfield

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37
Q

Alpha-numeric terminology

A

Rosenfield

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38
Q

Rh1

A

D

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39
Q

Rh2

40
Q

Rh3

41
Q

Rh4

42
Q

Rh5

43
Q

R1r
Fisher-Race:
Rosenfield:
Common or Rare

A

DCe/dce
1,2,-3,4,5
Common

44
Q

R1R1
Fisher-Race:
Rosenfield:
Common or Rare

A

DCe/DCe
1,2,-3,-4,5
Common

45
Q

rr
Fisher-Race:
Rosenfield:
Common or Rare

A

dce/dce
-1,-2,-3,4,5
Common

46
Q

R1R2
Fisher-Race:
Rosenfield:
Common or Rare

A

DCe/DcE
1,2,3,4,5
Common

47
Q

R2r
Fisher-Race:
Rosenfield:
Common or Rareo

A

DcE/dce
1,-2,3,4,5
Common

48
Q

R2R2
Fisher-Race:
Rosenfield:
Common or Rare

A

DcE/DcE
1,-2,-3,4,-5
Common

49
Q

r’r
Fisher-Race:
Rosenfield:
Common or Rare

A

dCe/dce
-1,2,-3,4,5
Rare

50
Q

r’r’
Fisher-Race:
Rosenfield:
Common or Rare

A

dCe/dCe
-1,2,-3,-4,5
Rare

51
Q

r”r
Fisher-Race:
Rosenfield:
Common or Rare

A

dcE/dce
-1,-2,3,4,5
Rare

52
Q

r”r”
Fisher-Race:
Rosenfield:
Common or Rare

A

dcE/dcE
-1,-2,3,4,5
Rare

53
Q

R0r (R0R0)
Fisher-Race:
Rosenfield:
Common or Rare

A

Dce/dce (Dce/Dce)
1,-2,-3,4,5
Rare

54
Q

r’r” (ryr)
Fisher-Race:
Rosenfield:
Common or Rare

A

dCe/dcE (dCE/dce)
-1,2,3,4,5
Rare

55
Q

D
ISBT:

56
Q

C
ISBT:

57
Q

E
ISBT:

58
Q

c
ISBT:

59
Q

e
ISBT:

60
Q

First 3 number of ISBT represents

A

the system collection and series

61
Q

Last 3 numbers of ISBT represents

A

antigenic specificity

62
Q

Rh antigens are well developed at birth and therefore easily cause ____

63
Q

Anti-D
incompatible %:
compatible %:

64
Q

Anti-C
incompatible %:
compatible %:

65
Q

Anti-E
incompatible %:
compatible %:

66
Q

Anti-c
incompatible %:
compatible %:

67
Q

Anti-e
incompatible %:
compatible %:

68
Q

Weak D (Du) is common in what race?

69
Q

Weak D is detected by

70
Q

Allele carrying RhD is in trans position to the allele carrying C

A

C in trans to RhD/ Positional D

71
Q

D antigen is expressed completely but fewer in numbers. Rarely makes anti-D sinces changes are inside RBCs

A

Genetic weak D

72
Q

One or more epitopes within the D antigen is missing altered

A

Partial D/D mosaic

73
Q

Partial D donor is considered

74
Q

Partial D recipient is considered

75
Q

D—/D—

A

Rh deletion

76
Q

—-/—-

77
Q

Normal RhD & RhE genes
RhAG expression

A

Regulator Rh null

78
Q

Normal RhAG gene
Mutated RhCE
Deleted RhD

A

Amorphic Rh null

79
Q

Partial suppression of Rh gened caused by RhAG mutation

80
Q

Compount antigen when c and e are in cis position

81
Q

Caused by single amino acid change on RhCE protein

82
Q

Compound antigen when C and e are present

83
Q

Present on D+C-/D-C+/D+C+
Not on D-C-

84
Q

Strong expression of D because of Cc/Ee expression

85
Q

Not naturally occuring antibodies and only form upon exposure such as pregnancy and transfusion

A

Rh antibodies

86
Q

Igs of Rh antibodies that are warm reacting and reacts at 37oC

87
Q

Most clinical significant IgG in Rh

A

IgG1 & IgG3

88
Q

Complement fixation IgG in Rh

A

IgG3 > IgG1 > IgG2

89
Q

Non-complement binding IgG in Rh

90
Q

Best Rh IgG at crossing placenta

A

IgG1 > IgG4 > IgG3

91
Q

Rh IgG that cannot cross placenta

92
Q

Most dominant Rh IgG in adults

A

IgG1 > IgG2 > IgG3 > IgG4

93
Q

HTRs due to Rh incompatibilities usually results in

A

Extravascular hemolysis in the liver and spleen

94
Q

How much of the exposure to Rh (+) can stimulate antibody production in an Rh (-)

95
Q

Warm Rh autoantibodies appears to what antibody specificity

A

Anti-E like specificity

96
Q

Warm Rh autoantibodies appears to what antibody specificity

A

Anti-E like specificity

Blood Banking (17 decks)

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