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Blood Banking > Major Non-ABO Blood Groups > Flashcards

Major Non-ABO Blood Groups Flashcards

1
Q

ISBT 016

A

LW blood group

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2
Q

Expressed together with Rh

A

Lw

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3
Q

LW gene is on what chromosome

A

Chromosome 19

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4
Q

LW antigen is carried by

A

Intracellular Adhesion Molecule 4

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5
Q

To differentiate D Ag from LW Ag

A

Treat cells with DTT
D Ag: Not denatured
LW Ag: Denatured

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6
Q

Anti-LW will react ____ with most D (+) cells

A

Strongly

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7
Q

Anti-LW will ____ with Rh (-) cells

A

Weakly

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8
Q

Anti-LW will _____ react with Rh null cells

A

Never react

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9
Q

Anti-LW will react ____ with cord cells regardless of D type

A

Equally

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10
Q

Only major system not produced by RBCs

A

Lewis system

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11
Q

Lewis Ag are found on ____ passively absorbed by RBCs in plasma

A

Type 1 glycosphyngolipids

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12
Q

Le gene is found on what chromosome

A

Chromosome 19

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13
Q

FUT3 gene

A

Le gene

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14
Q

Type of sugar derivative of Le Ag found in secretions

A

Glycoproteins

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15
Q

Type of sugar derivative of Le Ag absorbed by RBCs in plasma

A

Glycolipid

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16
Q

Le (a+b+) is possible in what race

A

Asians

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17
Q

lele is common in

A

Blacks

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18
Q

T/F: Lewis Ag not present at birth, not expressed on cord cells

A

T

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19
Q

Le Ag development in Secretor

A

Le(a-b-) > Le(a+b-) > Le(a+b+) > Le(a-b+)

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20
Q

Le Ag development of Non-secretor

A

Le(a-b-) > Le(a+b-)

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21
Q

When is Leb Ag present?

A

If Le and Se are present

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22
Q

Genes Inherited: Le Se ABH
Substance in Secretions:
Red cell Phenotype:

A

Lea, Leb, ABH
Le(a-b+) ABH

23
Q

Genes Inherited: lele Se ABH
Substance in Secretions:
Red cell Phenotype:

A

ABH
Le(a-b-) ABH

24
Q

Genes Inherited: Le sese ABH
Substance in Secretions:
Red cell Phenotype:

A

Lea
Le(a+b-) ABH

25
Q

Genes Inherited: lele sese ABH
Substance in Secretions:
Red cell Phenotype:

A

None
Le(a-b-) ABH

26
Q

Genes Inherited: Le sese AB hh
Substance in Secretions:
Red cell Phenotype:

A

Lea
Le(a+b-) Oh/H null (bombay)

27
Q

Genes Inherited: Le sese AB hh
Substance in Secretions:
Red cell Phenotype:

A

Lea
Le(a+b-) Oh/H null (bombay)

28
Q

Genes Inherited: Le Se AB hh
Substance in Secretions:
Red cell Phenotype:

A

Lea, Leb, ABH type 1 Ag
Le(a-b+) Ah or Bh (parabombay)

29
Q

Anti-Lea, Anti-Leb
1) IgM
2) Naturally occuring
3) Cold reactive
A. 1
B. 1,2&3
C. 1&3
D. 1&2

30
Q

Leb is associated with

A

H. Pylori infection

31
Q

MNS gene is found in what chromosome?

A

Chromosome 4

32
Q

Antigens of MNS system

A

M, N, S, s

33
Q

Paternity tested Ag

34
Q

Stronger reactions demonstrated from an antibody to a homozygous cell than a heterozygous cell

A

Dosage effect

35
Q

Location of MN Ag

A

Glycophorin A

36
Q

M and N differ at position 1 and 5 with what amino acids?

A

M: 1-serine; 5-glycine
N: 1-leucine, 5-glutamic acid

37
Q

Location of Ss Ag

A

Gylcophorin B

38
Q

S and s Ag differ at position 29 with what amino acid?

A

S: methionine
s: threonine

39
Q

S+s+ what phenotype?

A

U phenotype

40
Q

MNS antibodies are in nature what?

A

IgM, naturally occuring and cold reactive

41
Q

Anti-M react at pH

A

pH 6.5 (acidic)

42
Q

Anti-N react at pH

A

alkaline pH

43
Q

Antibody sterilized with formaldehyde

44
Q

Anti-S & Anti-s in nature

A

IgG; reactive 37oC & AHG phase

45
Q

S-s-

46
Q

Anti-U is common in

47
Q

GPA is recepector for

48
Q

GPA and GPB receptor for

A

Plasmodium falciparum

49
Q

ISBT 002

A

MNS system

50
Q

ISBT 003

A

P blood group

51
Q

Ag that deteriorates rapidly upon storage

52
Q

Phenotype: P1
Ag:
Ab:

A

P1, P, Pk
None

53
Q

Phenotype: P2
Ag:
Ab:

A

P, Pk
Anti-P1

54
Q

Phenotype: p (P null)
Ag:
Ab:

A

None
Anti-PP1Pk/Anti-Tja

Blood Banking (17 decks)

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