Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

[1ST YEAR] PH 105 - Pharmaceutical Analysis I (Lec) > REVIEWER 01 - Quality Control (Red) > Flashcards

REVIEWER 01 - Quality Control (Red) Flashcards

1
Q

Titrant employed for non-aqueous alkalimetric titration:
A. Ammonium Hydroxide
B. Hydrochloric Acid VS
C. Perchloric Acid in Glacial Acetic Acid VS
D. Potassium Hydroxide VS
E. Sodium Methoxide VS

A

E. Sodium Methoxide VS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

USP specifies that the standardization of Sodium Hydroxide VS should be done using ______ as
standard:
A. Hydrochloric Acid VS
B. Sodium Carbonate
C. Tromethamine
D. Potassium Biphthalate
E. Potassium Dichromate

A

D. Potassium Biphthalate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Volhard Method in volumetric precipitation involves the use of what indicator?
A. Eosin TS
B. Ferric Ammonium Sulfate TS
C. Phenolphthalein TS
D. Potassium Chromate TS
E. Orthophenanthroline TS

A

B. Ferric Ammonium Sulfate TS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Nitrogen content determination of foods and pharmaceuticals involves what method?
A. Fajan’s method
B. Gay-Lussac method
C. Kjeldahl method
D. Gravimetric method
E. Winkler method

A

C. Kjeldahl method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fat constant that states the degree of unsaturation
in fats and fixed oils:
A. Polenske number
B. Koettsdorfer number
C. Unsaponifiable matter
D. Iodine number
E. Acetyl number

A

D. Iodine number

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

An example of drying oil:
A. Cod liver oil
B. Olive oil
C. Coconut oil
D. Sesame oil
E. Lard

A

A. Cod liver oil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Orthophenanthroline TS undergoes a color transition from ______ to ______:
A. Colorless to pink
B. Yellow to red
C. Red to blue
D. White to black
E. Blue to yellow

A

C. Red to blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Equivalence factor for potassium permanganate as an oxidizing agent:
A. 2
B. 3
C. 5
D.10
E. 23

A

C. 5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

pH-adjusting agent used in EDTA titrations using Dithizone TS as indicator:
A. 3N HCL
B. CH3COOH-CH3COONa buffer
C. NH3-NH4Cl buffer
D. 1N NaOH
E. Any of the choices

A

B. CH3COOH-CH3COONa buffer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Acid color of phenol red:
A. Colorless
B. Red
C. Blue
D. Yellow
E. Green

A

D. Yellow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Reducing titrant that is susceptible to bacterial
degradation:
A. Oxalic Acid VS
B. Potassium Permanganate VS
C. Sodium Thiosulfate VS
D. Ferrous Ammonium Sulfate VS
E. Ceric Sulfate VS

A

C. Sodium Thiosulfate VS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Assay involves an acidimetric type of titration:
A. Determination of total alkalinity of NaOH
B. Phosphomolybdate assay for phosphates
C. Assay of Precipitated Sulfur using oxygen flask
combustion
D. Assay of Cupric Sulfate
E. Assay of Zinc Chloride

A

A. Determination of total alkalinity of NaOH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Type of crucible that can withstand high
temperature and is suitable for use in ignition of drugs
and precipitates:
A. Borosilicate Glass
B. Sintered crucible
C. Porcelain
D. B and C
E. A, B and C

A

C. Porcelain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Measures the free fatty acid present in a given
sample of fats of fixed oil:
A. Acid Value
B. Ester Value
C. Crude Fiber
D. Iodine Value
E. Unsaponifiable Matter

A

A. Acid value

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Assay method for Sodium Hypochlorite Solution,
USP:
A. Acidimetry
B. EDTA titration
C. Iodometry
D. Permanganometry
E. Volumetric precipitation

A

C. Iodometry

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Official method of water content determination of
pharmaceutical samples:
A. Azeotropic distillation
B. Gravimetric determination
C. Karl Fischer method
D. A and C
E. A, B and C

A

E. A, B, and C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The use of potassium chromate TS as indicator in
Volumetric precipitation is also known as the ______
method:
A. Fajan’s Method
B. Gay-Lussac Method
C. Mohr Method
D. Dumas Method
E. Volhard Method

A

C. Mohr Method

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Solve for the acid number of a 2g sample of cod liver oil which required 4.5mL of 0.02 KOH in the titration. (MW of KOH 56.11g/mol):
A. 0.25%
B. 2.5%
C. 25mg/g
D. 2.5mg/g
E. 0.25mg/g

A

D. 2.5 mg/g

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

EDTA titration using dithizone TS as indicator
should be conducted at what pH?
A. 2
B. 4.6
C. 7
D. 10
E. 13

A

B. 4.6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

This value represents the percentage of test
material which is volatilized and driven off under the
condition specified:
A. Water content Determination
B. Ignition to constant weight
C. Loss on drying
D. Loss on ignition
E. Acid insoluble ash

A

D. Loss on ignition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Potassium biphthalate is a primary standard used
for standardization of ______:
A. Sulfuric Acid VS
B. Sodium Hydroxide VS
C. Ammonium Thiocyanate VS
D. Potassium Permanganate VS
E. Disodium Edetate VS

A

B. Sodium Hydroxide VS

21
Q

Tromethamine is a primary standard used for the
standardization of what VS?
A.Sodium Nitrite VS
B. Ammonium Thicyanate VS
C. Sulfuric Acid VS
D. Silver Nitrate VS
E. Perchloric Acid VS

A

C. Sulfuric Acid VS

21
Q

Purpose of potassium iodide in preparation of
Iodine VS:
A. To protect iodine from microbial degradation
B. To permit dissolution of iodine in water
C. As an Antioxidant
D. A and B
E. A, B and C

A

B. To permit dissolution of iodine in water

21
Q

The acid value of a certain fixed oil is .96 and the
ester value is 2.48. What is the saponification number
of the sample?
A. 0.50
B. 2.48
C. 3.72
D. 7.44
E. 12.30

A

D. 7.44

22
Q

Alcoholic hydroxyl groups present in fatty acids is
estimated using what fat constant?
A. Acetyl value
B. Acid value
C. Unsaponifiable matter
D. Iodine value
E. Ester value

A

A. Acetyl value

22
Q

Reproducibility of data within a series of results is
usually reported as:
A. Absolute error
B. Relative error
C. Standard deviation
D. t-test
E. Q-test

A

C. Standard deviation

23
Q

Appropriate indicator for a strong acid-weak base
titration:
A. Phenolphthalein
B. Methyl red
C. Eriochrome black T
D. Diphenylamine
E. Starch

A

A. Phenolphthalein

24
Q

Equivalence factor when arsenic trioxide is used
for standardization of iodine VS:
A. 1
B. 2
C. 3
D. 4
E. 5

A

D. 4

25
Q

Titrimetric assay for ferrous salts employ what
method?
A. Cerimetry
B. Acidimetry
C. Iodometry
D. Precipitimetry
E. Gravimetry

A

A. Cerimetry

26
Q

Equivalence factor for sodium thiosulfate:
A. 1
B. 2
C. 3
D. 6
E. 10

A

A. 1

27
Q

A parameter that denotes the nearness of the
experimental data of the true value:
A. Accuracy
B. Deviation
C. Precision
D. Ruggedness
E. B and C

A

A. Accuracy

28
Q

What is the pH of a 0.1M solution of acetic acid?
(Ka=1.75x10-5):
A. 5.00
B. 2.88
C. 4.76
D. 7.00
E. 9.24

A

B. 2.88

29
Q

The direct or residual titrimetric determination of
organic or inorganic acids using an accurately
measured volume of base:
A. Acidimetry
B. Alkalimetry
C. Potentiometric titration
D. Precipitimetry
E. Oxidimetry

A

B. Alkalimetry

30
Q

Equivalence factor for dichromate ion when it
acts as an oxidizing agent:
A. 2
B. 3
C. 6
D. 7
E. 10

A

C. 6

31
Q

Assayed residually by EDTA titration:
A. Calcium carbonate
B. Aluminum hydroxide
C. Zinc sulfate
D. Acetic acid
E. Sodium thiosulfate

A

C. Zinc sulfate

32
Q

A self-indicating volumetric solution:
A. Iodine VS
B. Ceric sulfate VS
C. Potassium permanganate VS
D. Ammonium thiocyanate VS
E. sodium hydroxide VS

A

C. Potassium permanganate VS

33
Q

Preferred titrant for the analysis of ferrous salts
in mixtures that contain excipient or diluents that have
a reducing action on permanganate:
A. Silver nitrate VS
B. Ceric sulfate VS
C. Sodium thiosulfate VS
D. Disodium EDTA VS
E. Hydrochloric acid VS

A

B. Ceric sulfate VS

34
Q

A substance of known purity that is used for
deyermination of the exact soncentration of a
volumetric solution:
A. Analyte
B. Blank determination
C. Equivalence factor
D. Primary standard
E. Titer value

A

D. Primary standard

35
Q

Kjeldahl method:
A. Water content deretmination
B. Nitrogen content determination
C. Oxygen flask combustion
D. Nonaqueous titration
E. Specific gravity determination

A

B. Nitrogen content determination

36
Q

Titanium Dioxide is assayed by what method?
A. Alkalimetry
B. Iodometry
C. Permanganometry
D. Gravimetry
E. Volumetric pricipitation

A

C. Permanganometry

37
Q

Temperature equivalent of dull-red heat:
A. 500-550°C
B. 550-700°C
C. 800-1000°C
D. 1000-1200°C
E. 1200-1600°C

A

B. 550-700°C

38
Q

Represent the inorganic salts naturally occurring
in the drug and adhering to it, but may also include
inorganic matter added for the purpose of
adulteration.
A. Ash content
B. Crude fiber
C. Loss on ignition
D. Water content
E. Unsaponifiable matter

A

A. Ash content

39
Q

A type of redox reaction that leads to n increase
in positive valence of a chemical species:
A. Oxidation
B. Reduction
C. Decomposition
D. Combustion
E. Displacement

A

A. Oxidation

40
Q

Failure to judge color change sharply during
titration can lead to what type of error?
A. Indeterminate error
B. Instrumental error
C. Methodic error
D. Personal error
E.. Number bias

A

D. Personal error

41
Q

Residue consisting chiefly of cellulose that remains undissolved after successive treatment with boiling acid and alkali:
A. Total ash
B. Crude Fiber
C. Sulfated Ash
D. Unsaponifiable Matter
E. Loss on Drying

A

B. Crude fiber

42
Q

Addition of an excess titrant to permit complete reaction of the analyte with the titrant and then the unreacted excess titrant with another
standard soulution:
A. Blank determination
B. Direct titration
C. Double titration
D. Residual titration
E. Displacement titration

A

D. Residual titration

43
Q

The weight of a substance chemically equivalent
to 1mL of a standard solution:
A. Equivalent weight
B. Titer
C. Molecular weight
D. Mole
E. Calibration standard

A

A. Equivalent weight

44
Q

Method II of water determination involves
A. Tartration
B. Azeotropic distillation
C.Gravimetry
D. Stoichiometry
E. NOTA

A

B. Azeotropic distillation

45
Q

Standard solution that is most susceptible to air oxidation?
A. Ferrous ammonium sulphate TS
B. Oxalic Acid VS
C. Sodium thiosufate VS
D. Titanium trichloride
E. Potassium arsenite

A

C. Sodium thiosulfate VS

46
Q

Suitable backtitrant for titration involving the use
of excess silver nitrate VS:
A. Ammonium thiosulfate VS
B. Sodium tetraphenylboron VS
C. Lithium methoxide VS
D. Potassium Ferrocyanide VS
E. Ceric Sulfate VS

A

A. Ammonium thiosulfate VS

[1ST YEAR] PH 105 - Pharmaceutical Analysis I (Lec) (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions