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[1ST YEAR] PH 105 - Pharmaceutical Analysis I (Lec) > PRELIM 01 - Pharmaceutical Analysis > Flashcards

PRELIM 01 - Pharmaceutical Analysis Flashcards

1
Q

Deals with methods for determining the chemical composition of states of matter

A

Analytical chemistry

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2
Q

Yields information about the identity of atomic or molecular species

A

Qualitative method

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3
Q

Provides numerical information as to the relative amount of one or more of these components

A

Quantitative method

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4
Q

3 classifications of drug analysis according to nature of sample

A

Physical, Chemical, Biological

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5
Q

The process of a quantitative determination of a chemical substance from a given sample

A

Assay

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6
Q

5 classifications of drug analysis according to size of sample

A

Macroanalysis, Semi-microanalysis, Microanalysis, Submicroanalysis, Ultramicroanalysis

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7
Q

0.1 g or more

A

Macroanalysis

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8
Q

0.1 g - 1 g

A

Semi-microanalysis

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9
Q

0.01 g - 0.1 g

A

Microanalysis

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10
Q

0.001 g - 0.01 g

A

Submicroanalysis

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11
Q

<0.001 g

A

Ultramicroanalysis

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12
Q

3 classifications of drug analysis according to extent of analysis

A

Proximate, Ultimate, Partial

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13
Q

Amount of each element in a sample is determined

A

Proximate

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14
Q

The perfect of extractive from a crude drug represents a single chemical species

A

Ultimate

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15
Q

Determines selected constituents in the sample

A

Partial

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16
Q

The sum total of the organized arrangements made with the object of ensuring that all APIs are of the quality required

A

Quality assurance (QA)

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17
Q

Checking or testing that specifications are met

A

Quality control (QC)

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18
Q

A branch of practical chemistry that involves a series of processes for identification, determination, quantification, and purification of a substance

A

Pharmaceutical analysis

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19
Q

3 Separation techniques (classical methods)

A

Precipitation, Extraction, Distillation

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20
Q

2 Separation techniques (instrumental methods)

A

Chromatography, Electrophoresis

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21
Q

7 Qualitative analysis techniques (classical methods)

A

Chemical tests, b.p., m.p., Solubility, Odor, Optical activity, Refractive index

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22
Q

4 Qualitative analysis techniques (instrumental methods)

A

UV/Vis spectrometry, Infrared spectrometry, MS, NMR spectrometry

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23
Q

3 Quantitative analysis techniques (classical methods)

A

Titrimetry, Gravimetry, Coulometry

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24
Q

6 Quantitative analysis techniques (instrumental methods)

A

Potentiometry, Voltammetry, Spectrophotometry, AAS, Thermometric methods, Kinetic methods

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25
Securing or getting a representative sample from a given population
Sampling
26
2 types of error
Indeterminate, Determinate
27
Random and inherent error; uncontrolled variable
Indeterminate error
28
Systematic error; flaw in equipment or design of the experiment
Determinate error
29
Reproducibility of the result
Precision
30
Other name of relative standard deviation
Coefficient of variation
31
Difference between the largest and smallest value
Range
32
Describes how close a measured value is to the "true" value
Accuracy
33
Difference between the mean value and true value
Absolute error
34
Absolute error divided by the true value
Relative error
35
Analytical method in which the volume of a solution of known concentration during analysis is taken as a measure of the amount of active constituent in a sample being analyzed
Titration
36
3 Titration methods
Volumetric titrations, Gravimetric titrations, Coulometric titrations
37
Measuring the volume of known concentration needed to react with analyte
Volumetric titrations
38
Mass instead of volume
Gravimetric titrations
39
Measure time required for complete electrochemical reaction
Coulometric titrations
40
Standard solution of known concentration
Titrant
41
Substance to be determined
Analyte
42
Added to produce an observable physical change
Indicator
43
Theoretical point reached when the titrant and analyte are chemically equivalent
Equivalence point/Stoichiometric point
44
When a physical change occurs that is associated with the condition of chemical equivalence
End point
45
Weight of the substance chemically equivalent to 1 mL of a standard solution
Titer
46
Weight of a substance in grams that is chemically equivalent to 1 gram-atom of hydrogen
Gram-Equivalent Weight (GEW)
47
5 Types of titration
Direct titration, Residual titration, Titration with blank test, Indirect titration, Double residual titration
48
Titrant is directly added to analyte until the reaction goes to completion
Direct titration
49
The volume of which that did not react with the analyte is then titrated
Residual/back titration
50
Sample experimental condition without sample; done to find out the effect of the impurities
Titration with blank test
51
2 Detection methods
Visual, Instrumental
52
Appearance/disappearance of color
Visual method
53
Colorimeters, Turbidimeters, Spectrophotometers
Instrumental method
54
5 grades of reagent
Technical grade/commercial, USP/NF, Analytical, Chemically pure, Primary standard grade
55
For general industrial use
Technical grade/commercial
56
Chemicals manufactured under current GMP and which meet the requirement of USP/NF
USP/NF
57
High quality chemical for laboratory use
Analytical
58
Products of purity suitable for use in general applications
Chemically pure
59
Analytical reagent of exceptional purity that is specially manufactured for standardizing volumetric solutions
Primary standard grade
60
Determination of exact concentration (normality or molarity) of a solution
Standardization
61
Highly purified compound; serves as a reference material for titration
Primary standard
62
Purity has been determined by chemical analysis; serves as the working standard material for titrations
Secondary standard
63
4 Chemical reactions in titrimetry
Neutralization, Oxidation-reduction, Precipitation, Complexation
64
Assay of alkaloids
Proximate
65
Assay of glycosides
Proximate
66
Assay of morphine
Ultimate
67
Assay of Ipecac
Proximate
68
Assay of opium
Proximate
69
Assay of hyocyamine from belladonna leaf
Ultimate
70
Assay of volatile oil from caraway oil
Proximate
71
Assay of total carvone content from an oil
Proximate
72
Assay of menthol from peppemint
Ultimate
73
Reading a scale among analysts
Determinate
74
Electrical noise
Indeterminate
75
Inability to distinguish color sharply
Indeterminate - Lec Determinate - Lab
76
Contamination of precipitates
Determinate
77
Incorrect sampling
Determinate
78
Incorrect weights
Determinate
79
Improper selection of indicators
Determinate

[1ST YEAR] PH 105 - Pharmaceutical Analysis I (Lec) (12 decks)

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