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Immunology > Review question answer > Flashcards

Review question answer Flashcards

1
Q

What cells differentiate into mast cells, which produce histamine in an allergic reaction?

A

Basophils

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2
Q

What transcription factor is required to terminally differentiate into the erythrocyte lineage?

A

GATA-1

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3
Q

NK CD Markers

A

CD16+

CD56+

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4
Q

Macrophage/monocyte CD Markers

A

CD14+

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5
Q

Mast cell CD Marker

A

CD23+

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6
Q

Dendritic cells CD Marker

A

CD80+

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7
Q

B Cell CD Marker

A

CD20+

CD19+

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8
Q

T cell CD Marker

A

CD3+

CD4+/CD8+

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9
Q

Neutrophil CD Marker

A

CD15+

CD16b+

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10
Q

What IL is responsible for the differentiation of HCS–> CLP?

A

IL-7

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11
Q

What IL is responsible for the differentiation of HCS–> CMP?

A

IL-3

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12
Q

Which IL activates Mast cells?

A

IL-12

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13
Q

What cells bridge the innate and adaptive immunity?

A

Dendritic cells

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14
Q

What is the second exposure to an antigen like?

A
  1. Response is larger (more antibodies released)

2. Response is faster

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15
Q

What happens when a lymphocyte is not activated by an antigen?

A

It will leave the lymphatics and go to the next lymphoid tissue.

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16
Q

Steps of lymphocyte migration

A
  1. Enter lymphoid tissue
  2. Follow cytokine signals
  3. No activation–> next lymhoid tissue
  4. Still no activation–> go to the thoracic duct and re-circulate
17
Q

What colony factors and interleukins do you need to develop a macrophage?

A

IL1
IL3
IL6
M-CSF

18
Q

Which of mechanism requires antibodies in order to activate fx/cascade?

A

Classical compliment pathwat

19
Q

Anti-inflammatory components

A

IL-10

TGF-B

20
Q

What hemopoietic growth factor stimulates the growth of neutrophils?

A

G-CSF

21
Q

What hemopoietic growth factor stimulates the growth of macrophages?

A

M-CSF

22
Q

What is a chemokine that attracts neutrophils to a site of injury?

A

IL-8

23
Q

What leukocyte do you usually find in pus>?

A

Neutrophils. Neutrophils generally die in the course of the battle.

24
Q

What causes the healing of tissue?

A

Macrophages;

Remember, they heal tissue as well.

25
Q

Clonal selection

A

occurs in the primary lymphoid organ WITHOUT EXPOSURE to antigen

Immunology (12 decks)

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