Review question answer Flashcards
What cells differentiate into mast cells, which produce histamine in an allergic reaction?
Basophils
What transcription factor is required to terminally differentiate into the erythrocyte lineage?
GATA-1
NK CD Markers
CD16+
CD56+
Macrophage/monocyte CD Markers
CD14+
Mast cell CD Marker
CD23+
Dendritic cells CD Marker
CD80+
B Cell CD Marker
CD20+
CD19+
T cell CD Marker
CD3+
CD4+/CD8+
Neutrophil CD Marker
CD15+
CD16b+
What IL is responsible for the differentiation of HCS–> CLP?
IL-7
What IL is responsible for the differentiation of HCS–> CMP?
IL-3
Which IL activates Mast cells?
IL-12
What cells bridge the innate and adaptive immunity?
Dendritic cells
What is the second exposure to an antigen like?
- Response is larger (more antibodies released)
2. Response is faster
What happens when a lymphocyte is not activated by an antigen?
It will leave the lymphatics and go to the next lymphoid tissue.
Steps of lymphocyte migration
- Enter lymphoid tissue
- Follow cytokine signals
- No activation–> next lymhoid tissue
- Still no activation–> go to the thoracic duct and re-circulate
What colony factors and interleukins do you need to develop a macrophage?
IL1
IL3
IL6
M-CSF
Which of mechanism requires antibodies in order to activate fx/cascade?
Classical compliment pathwat
Anti-inflammatory components
IL-10
TGF-B
What hemopoietic growth factor stimulates the growth of neutrophils?
G-CSF
What hemopoietic growth factor stimulates the growth of macrophages?
M-CSF
What is a chemokine that attracts neutrophils to a site of injury?
IL-8
What leukocyte do you usually find in pus>?
Neutrophils. Neutrophils generally die in the course of the battle.
What causes the healing of tissue?
Macrophages;
Remember, they heal tissue as well.
Clonal selection
occurs in the primary lymphoid organ WITHOUT EXPOSURE to antigen
